Is CD38 involved in Ca<sup>2+</sup> signalling elicited by activation of T cell receptors?

Petersen, Ole H

Is CD38 involved in Ca²⁺ signalling elicited by activation of T cell receptors?

Petersen, Ole H.

Petersen OH; School of Biosciences, Cardiff University, Cardiff CF10 3AT, Wales, United Kingdom. Electronic address: Petersenoh@cardiff.ac.uk.

Cell Calcium ; 101: 102524, 2022 01.

Article in English | MEDLINE | ID: covidwho-1914206

ABSTRACT

ABSTRACT

A recent publication proposes that T cell receptor activation elicits formation of the Ca2+ releasing messenger NAADP from NAADPH, catalysed by the NADPH oxidase DUOX. This is in contrast to the hitherto prevailing view that CD38 is critical for NAADP formation. Is it time to reassess the role of CD38?

Subject(s)

Calcium; Membrane Glycoproteins; ADP-ribosyl Cyclase 1/metabolism; Calcium/metabolism; Calcium Signaling; Membrane Glycoproteins/metabolism; NADP/metabolism; Receptors, Antigen, T-Cell

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Membrane Glycoproteins / Calcium Language: English Journal: Cell Calcium Year: 2022 Document Type: Article

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