Updates in the Management of Warm Autoimmune Hemolytic Anemia.
Hematol Oncol Clin North Am
; 36(2): 325-339, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1914449
ABSTRACT
Warm autoimmune hemolytic anemia (wAIHA) is an uncommon and heterogeneous disorder caused by autoantibodies to RBC antigens. Initial evaluation should involve the DAT, with wAIHA typically IgG positive with or without C3 positivity, and a search for underlying conditions associated with secondary wAIHA, which comprise 50% of cases. First-line therapy involves glucocorticoids, increasingly with rituximab, though a chronic relapsing course is typical. While splenectomy and a number of immunosuppressive therapies have been used in the setting of relapsed and refractory disease, the optimal choice and sequence of therapies is unknown, and clinical trials should be offered when available. Newer investigational targets include spleen tyrosine kinase inhibitors, monoclonal antibodies targeting CD38, Bruton's tyrosine kinase inhibitors, complement inhibitors, and antibodies against neonatal Fc receptors.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Anemia, Hemolytic, Autoimmune
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
Limits:
Humans
/
Infant, Newborn
Language:
English
Journal:
Hematol Oncol Clin North Am
Journal subject:
Hematology
/
Neoplasms
Year:
2022
Document Type:
Article
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