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Hypermagnesemia and hyperphosphatemia are highly prevalent in patients with COVID-19 and increase the risk of death.
Malinowska, Justyna; Malecka-Gieldowska, Milena; Bankowska, Diana; Borecka, Kinga; Ciepiela, Olga.
  • Malinowska J; Department of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland; Doctoral School at Medical University of Warsaw, Warsaw, Poland. Electronic address: justyna.malinowska@wum.edu.pl.
  • Malecka-Gieldowska M; Department of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland; Central Laboratory, Central Teaching Hospital of University Clinical Center of Medical University of Warsaw, Warsaw, Poland.
  • Bankowska D; Students Scientific Group of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland.
  • Borecka K; Students Scientific Group of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland.
  • Ciepiela O; Department of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland; Central Laboratory, Central Teaching Hospital of University Clinical Center of Medical University of Warsaw, Warsaw, Poland.
Int J Infect Dis ; 122: 543-549, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1914484
ABSTRACT

OBJECTIVES:

Nonrespiratory manifestations of COVID-19 include endocrine disorders, among which are calcium-magnesium-phosphate homeostasis abnormalities, which seem to influence the disease severity and patient outcome. The aim of this study was to evaluate the prevalence and impact of calcium-magnesium-phosphate and vitamin D3 disorders on survival in patients hospitalized for COVID-19 depending on the severity of the disease and kidney function. DESIGN OR

METHODS:

The study was conducted between April 2020 and May 2021 at Central Clinical Hospital in Warsaw, Poland. A total of 146 patients who had tested concentration of at least one of the studied elements, estimated glomerular filtration ratio, creatinine levels, and blood saturation, and were diagnosed with COVID-19 disease were included in the analysis.

RESULTS:

We found that hypermagnesemia was common and associated with a 1.5-fold increased risk of death in the whole cohort. Hyperphosphatemia also increased the risk of death, exactly 2.4-fold. Furthermore, we found a statistically significant association between increased mortality in the whole cohort and hypovitaminosis D3 (P <0.05). Serum creatinine concentration and estimated glomerular filtration ratio significantly correlated with serum magnesium and phosphate levels.

CONCLUSION:

Hypermagnesemia, hyperphosphatemia, and hypovitaminosis D but not hypocalcemia influence the mortality of patients with COVID-19. These parameters should be monitored routinely in this group of patients, especially in those with decreased kidney function.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hyperphosphatemia / COVID-19 / Metabolic Diseases Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hyperphosphatemia / COVID-19 / Metabolic Diseases Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article