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Successful treatment of ascending aortic thrombosis associated with coronavirus disease 2019: Case report.
Miyawaki, Norihisa; Kinoshita, Makoto; Furukawa, Yutaka.
  • Miyawaki N; Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Kinoshita M; Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Furukawa Y; Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
J Cardiol Cases ; 26(4): 305-307, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1914559
ABSTRACT
Coronavirus disease 2019 (COVID-19) has been associated with arterial thrombosis, including aortic thrombus with embolism as well as venous thrombosis. We report a case of a 59-year-old man with COVID-19 showing thrombus in the ascending aorta and occlusion of the lower limb artery on computed tomography. Anticoagulant therapy via continuous intravenous infusion of heparin was started with a therapeutic target range (activated partial thromboplastin time 42-70 s, 1.5-2.5 × patient baseline). The patient was then transferred to warfarin medication and prothrombin time-international normalized ratio was managed at 1.5-2.5. The disappearance of the thrombus was confirmed on the 20th day after starting anticoagulant therapy. Anticoagulant therapy was then discontinued, and computed tomography angiography (CTA) 3 months later showed no recurrence of aortic thrombi or embolism. Anticoagulant therapy alone may be considered for arterial thrombosis in COVID-19 and follow-up CT may allow for early discontinuation of anticoagulant therapy to confirm disappearance of thrombus. Learning

objective:

Coronavirus disease 2019 (COVID-19) is recognized to cause arterial thrombosis as well as venous thrombosis. However, treatment of aortic thrombosis in patients with COVID-19 has not yet been established. Anticoagulants alone may be effective against aortic thrombi in patients with COVID-19 and follow-up computed tomography may allow for early discontinuation of anticoagulant therapy to confirm disappearance of thrombus.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study Language: English Journal: J Cardiol Cases Year: 2022 Document Type: Article Affiliation country: J.jccase.2022.06.003

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study Language: English Journal: J Cardiol Cases Year: 2022 Document Type: Article Affiliation country: J.jccase.2022.06.003