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Mesenchymal stem cells: a new front emerges in coronavirus disease 2019 treatment.
Raza, Syed Shadab; Khan, Mohsin Ali.
  • Raza SS; Department of Stem Cell Biology and Regenerative Medicine, Era's Lucknow Medical College Hospital, Era University, Lucknow, Uttar Pradesh, India. Electronic address: drshadab@erauniversity.in.
  • Khan MA; Era University, Lucknow, Uttar Pradesh, India.
Cytotherapy ; 24(8): 755-766, 2022 08.
Article in English | MEDLINE | ID: covidwho-1914577
ABSTRACT
Currently, treating coronavirus disease 2019 (COVID-19) patients, particularly those afflicted with severe pneumonia, is challenging, as no effective pharmacotherapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists. Severe pneumonia is recognized as a clinical syndrome characterized by hyper-induction of pro-inflammatory cytokine production, which can induce organ damage, followed by edema, dysfunction of air exchange, acute respiratory distress syndrome, acute cardiac injury, secondary infection and increased mortality. Owing to the immunoregulatory and differentiation potential of mesenchymal stem cells (MSCs), we aimed to outline current insights into the clinical application of MSCs in COVID-19 patients. Based on results from preliminary clinical investigations, it can be predicted that MSC therapy for patients infected with SARS-CoV-2 is safe and effective, although multiple clinical trials with a protracted follow-up will be necessary to determine the long-term effects of the treatment on COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cells / COVID-19 Type of study: Cohort study / Prognostic study Limits: Humans Language: English Journal: Cytotherapy Journal subject: Therapeutics Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cells / COVID-19 Type of study: Cohort study / Prognostic study Limits: Humans Language: English Journal: Cytotherapy Journal subject: Therapeutics Year: 2022 Document Type: Article