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COVID-19 & differential effects in twins: Insights from Placenta Pathology.
Moriarty, Kristen; Yu, Mingfu; Hussain, Naveed; Zgutka, Kinga; Sanders, M Melinda; Harigopal, Malini; Wang, Jianhui; Wang, Xi; Hui, Pei; Liu, Chen; Sink, David; Shields, Andrea.
  • Moriarty K; Department of Obstetrics & Gynecology, University of Connecticut, USA. Electronic address: kmoriarty@uchc.edu.
  • Yu M; Department of Pathology, University of Connecticut, USA.
  • Hussain N; Department of Pediatrics, Connecticut Children's Medical Center, USA.
  • Zgutka K; Department of Pediatrics, Connecticut Children's Medical Center, USA.
  • Sanders MM; Department of Pathology, University of Connecticut, USA.
  • Harigopal M; Department of Pathology, Yale University, USA.
  • Wang J; Department of Pathology, Yale University, USA.
  • Wang X; Department of Pathology, Yale University, USA.
  • Hui P; Department of Pathology, Yale University, USA.
  • Liu C; Department of Pathology, Yale University, USA.
  • Sink D; Department of Pediatrics, Connecticut Children's Medical Center, USA.
  • Shields A; Department of Obstetrics & Gynecology, University of Connecticut, USA.
Placenta ; 124: 62-66, 2022 06 24.
Article in English | MEDLINE | ID: covidwho-1914906
ABSTRACT

INTRODUCTION:

COVID-19 has been associated with several adverse pregnancy outcomes, including perinatal loss. Differential effects of COVID-19 in a twin pregnancy may provide unique insights into virus-placental interactions. We present a case of perinatal loss of a female fetus with survival of the male co-twin in a pregnancy complicated by COVID-19 and premature delivery.

METHODS:

Viral detection methods recommended by the NICHD task force were used to identify SARS-CoV-2 and its viral receptors in the placentas and fetal tissue (Antoun et al., 2020) [1]

RESULTS:

Compared with the surviving twin, we found a more severe intervillous necrosis and a relatively low detection of ACE2 membranous expression in the syncytiotrophoblasts of the female twin that succumbed.

DISCUSSION:

The interactions of SARS-CoV-2 and ACE2 at the maternal fetal interface within the placenta may play a significant role in perinatal loss, and the effects of fetal sex and gestational age at time of infection need to be explored further.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Case report / Experimental Studies / Prognostic study Limits: Female / Humans / Male / Pregnancy Language: English Journal: Placenta Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Case report / Experimental Studies / Prognostic study Limits: Female / Humans / Male / Pregnancy Language: English Journal: Placenta Year: 2022 Document Type: Article