Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
Commun Med (Lond)
; 2: 76, 2022.
Article
in English
| MEDLINE | ID: covidwho-1915298
ABSTRACT
Background:
The emergence of the new SARS-CoV-2 Omicron variant, which is known to have a large number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination.Methods:
Based on viral microneutralization assays, we evaluated in 90 individuals the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme.Results:
Here we show that the percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 16.6% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times.Conclusions:
These results indicate a positive impact of this vaccine combination in the serological immune response against SARS-CoV-2 Omicron variant.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
Topics:
Vaccines
/
Variants
Language:
English
Journal:
Commun Med (Lond)
Year:
2022
Document Type:
Article
Affiliation country:
S43856-022-00141-4
Similar
MEDLINE
...
LILACS
LIS