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Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters.
Rissmann, Melanie; Noack, Danny; van Riel, Debby; Schmitz, Katharina S; de Vries, Rory D; van Run, Peter; Lamers, Mart M; Geurts van Kessel, Corine H; Koopmans, Marion P G; Fouchier, Ron A M; Kuiken, Thijs; Haagmans, Bart L; Rockx, Barry.
  • Rissmann M; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Noack D; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • van Riel D; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Schmitz KS; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • de Vries RD; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • van Run P; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Lamers MM; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Geurts van Kessel CH; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Koopmans MPG; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Fouchier RAM; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Kuiken T; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Haagmans BL; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
  • Rockx B; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Emerg Microbes Infect ; 11(1): 1778-1786, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-1915483
ABSTRACT
The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to reduced pathogenicity of the virus or due to pre-existing immunity from vaccination or previous infection. Here, we inoculated hamsters with Omicron BA.1 to evaluate pathogenicity and kinetics of viral shedding, compared to Delta (B.1.617.2) and to animals re-challenged with Omicron BA.1 after previous SARS-CoV-2 614G infection. Omicron BA.1 infected animals showed reduced clinical signs, pathological changes, and viral shedding, compared to Delta-infected animals, but still showed gross- and histopathological evidence of pneumonia. Pre-existing immunity reduced viral shedding and protected against pneumonia. Our data indicate that the observed decrease of disease severity is in part due to intrinsic properties of the Omicron BA.1 variant.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Emerg Microbes Infect Year: 2022 Document Type: Article Affiliation country: 22221751.2022.2095932

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Emerg Microbes Infect Year: 2022 Document Type: Article Affiliation country: 22221751.2022.2095932