THE ROLE OF PULMONARYACT IN THE PATIENT WITH SARS-COV-2 INFECTION
European Heart Journal, Supplement
; 24(SUPPL C):C96-C97, 2022.
Article
in English
| EMBASE | ID: covidwho-1915557
ABSTRACT
Already from the first data in China it emerged that patients with cardiovascular comorbidities had an increased risk of contracting SARS-CoV-2 infection and a more unfavourable clinical course. From March to May 2020, 85 patients affected by COVID-19 were enrolled, hospitalized at the Hospital of Reggio Calabria. All patients underwent anamnesis, clinical evaluation, chest CT, ECG and measurement of markers of cardiovascular damage (Troponin I, CK-MB, LDH, D-dimer, BNP) and of inflammation (PCR, IL-6, and PCT). Thirty-one patients underwent echocardiography. In particular, we evaluated parietal dimensions and thicknesses, biventricular function and transvalvular tricuspid and pulmonary flows and correlated the data obtained with ECG, radiological, clinical, and biohumoral parameters. The aim of our study was to evaluate the prognostic impact of cardiovascular involvement in COVID- 19, investigating the effect of cardiovascular risk factors, levels of cardiovascular damage markers and newly emerging ECG and echocardiographic changes on a composite primary endpoint, consisting of the combination of death and the need for intensive care (ICU). The enrolled patients were divided into two subpopulations those with better prognosis and those with poorer prognosis (ICU/exitus). We analysed the reciprocal correlation of each of the parameters and searched for the presence of echocardiographic signs of repercussion on the right sections of the pulmonary pathology. All markers of cardiovascular damage had significantly higher values in the most critically ill patients and similar behaviour had indices of inflammation. Patients with poorer prognosis had significantly lower lung AcT values, which correlated with higher D-dimer levels and more complicated hospital stays. There were no statistically significant differences between PAPs, right ventricular size, TAPSE and pulmonary trunk diameter in the two subpopulations. Larger right ventricular diameters were associated with more dilated lung trunks and higher IL-6 levels. The most interesting data of our study is the behaviour of pulmonary AcT lower values of AcT were associated with higher levels of D-dimer, expression of a greater pulmonary microthrombotic burden, and a poorer prognosis, in the presence of PAPs normal. The dynamic analysis of this parameter, which is easy to calculate in the patient's bed, can play a crucial role in the instrumental follow-up of patients hospitalized for SARS-CoV-2 infection.
creatine kinase MB; D dimer; endogenous compound; interleukin 6; troponin I; adult; anamnesis; cardiovascular risk factor; clinical evaluation; conference abstract; controlled study; coronavirus disease 2019; critically ill patient; echocardiography; electrocardiogram; electrocardiography; female; follow up; gene expression; heart injury; heart right ventricle; hospitalization; human; inflammation; intensive care; lung blood flow; lung disease; major clinical study; male; prognosis; pulmonary artery; thickness; thorax; tricuspid annular plane systolic excursion; tricuspid valve; trunk
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
European Heart Journal, Supplement
Year:
2022
Document Type:
Article
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