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COMPARISON OF ACUTE KIDNEY FAILURE IN PATIENTS WITH SARS-COV-2 INFECTION DURING THE FIRST AND SECOND WAVES IN A THIRD-LEVEL HOSPITAL IN ANDALUSIA
Nephrology Dialysis Transplantation ; 37(SUPPL 3):i209, 2022.
Article in English | EMBASE | ID: covidwho-1915691
ABSTRACT
BACKGROUND AND

AIMS:

The incidence of acute renal failure (ARF) is frequent and has an implication in the morbidity and mortality of SARS-CoV-2 infection.

METHOD:

A retrospective descriptive study of patients admitted for SARS-CoV-2 infection during the first (G1) and second (G2) waves who presented with ARF. They correspond to the period from March to May 2020 (G1) and from August to December 2020 (G2). We compare populations, outcomes and treatments.

RESULTS:

A total of 73 patients in the first wave (G1), with a cumulative incidence (CI) of 28.3% (G1), compared with 58 patients in the second wave (G2), with a CI of 8% (G2). The mean age was higher in G2 [65.8 ± 15 years (G1);75.3 ± 14 (G2);P <.05], with no difference regarding sex [63% (G1);54% (G2)]. In G2, there was a higher proportion of patients with cardiovascular disease [23% (G1);57% (G2)], hypertension [56% (G1);83% (G2)]. The baseline glomerular filtration rate (GFR) being similar for both groups (CKD EPI 69 mL/min/1.732 (G1);P = .27). In the first wave, the mean days from admission to ARF was 3.1 days ± 4.2, and 42% of the patients were diagnosed at admission (31 patients). In the second, it was 2.9 days ± 5.7, of which 60% at admission (35 patients). The most prevalent cause was prerenal in both. Higher proportion in G1 of KDIGO stage 3 (G1 30% versus G2 17%) and renal replacement therapy (RRT) (G1 9 versusG2 2 patients). Only 3 patients remained in RRT in G1 and 1 patient in G2. In G1, 64% recovered their GFR [mean time (MT) 7.5 ± 8 days], and the percentage of deaths was 34%. In G2, 72% recovered GFR (MT 16 ± 25 days), and 19% of patients died.

CONCLUSION:

Despite a lower age and comorbidity of the first wave patients, the severity and lethality was higher. There were no differences in the proportion of patients who recovered their baseline renal function, although the recovery time was longer in the second wave. (Table Presented).
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Nephrology Dialysis Transplantation Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Nephrology Dialysis Transplantation Year: 2022 Document Type: Article