VITAMIN D STATUS AND SARS-COV-2 INFECTION IN A COHORT OF RENAL TRANSPLANTED PATIENTS
Nephrology Dialysis Transplantation
; 37(SUPPL 3):i698, 2022.
Article
in English
| EMBASE | ID: covidwho-1915792
ABSTRACT
BACKGROUND AND AIMS:
Immunomodulatory and anti-inflammatory properties have been hypothesized for native vitamin D (nVD). Very little is reported about nVD and risk of Sars-CoV-2 infection (COV) in renal transplant (RTx). In a cohort of renal transplanted patients (RTxp) we retrospectively evaluated (i) nVD status in patients with (COV+) and without (COV-) COV infection;(ii) the impact of nVD status on severity of COV.METHOD:
The study includes 61 COV + in whom nVD status was available in the year before the infection, and 122 COV- matched 12 for age (53[45-64]years), gender (M = 60.7%), RTx vintage (7[2-15] years), presence of diabetes (18%), arterial hypertension (85%) and cardiac symptomatic disease (3%). Renal function, 24-h proteinuria and mineral metabolism (MM) parameters were evaluated at 1, 6 and 12 months before COV whereas nVD status was considered as the mean 25- OH-VD levels at the same timepoints. Severity of COV was based on the need for hospitalization (HOSP+ 27/61, 44.3%) and death (D+ 6/61, 9.8%).RESULTS:
(i) nVD levels were significantly lower in COV + than in COV- (19[12- 26] ng/mL and 23[16-30] ng/mL, respectively, P = 0.01). No differences in the other biochemical parameters were found. The COV discriminative power of nVD status was evaluated by ROC curve (AUC 0.61, 95% CI 0.54-0.68, P = 0.01), with a value of 25-OHVD 23.9 ng/mL showing the best discriminative power (sensibility 72%, specificity 47%). (ii) nVD levels showed a trend towards lower values in HOSP + COV + than HOSP-COV+ (17[8-25] ng/mL versus 20[14-26] ng/mL) and in D + COV + than D-COV+ (13[6-23] ng/mL versus 20[13-26] ng/mL), although these differences did not reach the statistical significance (P = 0.1 and P = 0.2, respectively).CONCLUSION:
With the limitations of the retrospective nature of the study and the small sample size, our data report that (i) COV + showed lower nVD levels in the year preceding the infection compared with controls with similar main demographic features and comorbid conditions (ii) No differences were found in renal function, proteinuria and other MM parameters between the two groups. No association was found between nVD levels in the year preceding the infection and COV severity.
endogenous compound; signal peptidase I; vitamin D; adult; cohort analysis; conference abstract; controlled study; coronavirus disease 2019; demography; diabetes mellitus; female; gender; heart; hospitalization; human; hypertension; kidney function; major clinical study; male; metabolism parameters; mineral metabolism; proteinuria; receiver operating characteristic; retrospective study; sample size; sensibility; statistical significance; vitamin blood level
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
English
Journal:
Nephrology Dialysis Transplantation
Year:
2022
Document Type:
Article
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