IS IT SAFE TO RECEIVE KIDNEYS FROM DECEASED KIDNEY DONORS WHO TESTED POSITIVE FOR COVID-19 INFECTION?
Nephrology Dialysis Transplantation
; 37(SUPPL 3):i723, 2022.
Article
in English
| EMBASE | ID: covidwho-1915799
ABSTRACT
BACKGROUND AND AIMS:
Our modern world is facing extraordinary circumstances while passing through a serious pandemic caused by the novel coronavirus (COVID-19) which may lead to multi-organ system failure and death. COVID-19 deaths may provide a potential source for kidneys available for transplantation. In our study, we are discussing the safety of receiving kidneys from donors who tested positive for the novel coronavirus.METHOD:
All renal transplant recipients registered in UNOS database who had their transplants between 1 March 2020 and 1 June 2021 were retrospectively reviewed. Patients who received kidney transplants from a deceased donor with positive PCR of COVID-19 test were included in our study. Patients were followed up till 1 July 2021. Data about recipient factors (age, sex, ethnicity, diabetes and date of renal transplant), transplant factors (type of induction therapy, maintenance immunosuppressive therapy, delayed graft functions, early post-operative rejection episodes, HLA mismatch, PRA level and cold ischemia time) and donor factors (age, sex, ethnicity, diabetes, hypertension, date of COVID-19 test and type of COVID-19 test) were collected. Outcome measured were post-transplant hospitalisation, acute rejection, delayed graft function, patient, and graft survival till the end of the follow-up.RESULTS:
Eighty-six transplant patients received kidneys from deceased donors who tested positive for COVID-19 infection using PCR test. Sixty patients received kidneys from deceased patients who tested positive for COVID-19 within 30 days pre-transplant. Twenty-six patients received kidneys from deceased patients who tested positive for COVID-19 between 30 and 90 days pre-transplant. Number of post-transplant hospitalisation and acute rejection episodes were nil. 19.76% of the patients had delayed graft functions. Graft loss occurred in one patient due to graft vein thrombosis. Patient survival was 100%.CONCLUSION:
Receiving kidneys from deceased donors who tested positive for COVID-19 infection seems safe and does not affect hospitalisation, acute rejection rates, graft or patient survival. Longer follow-up is needed to confirm our results.
acute graft rejection; adult; age; cold ischemia time; conference abstract; controlled study; coronavirus disease 2019; COVID-19 testing; deceased donor; delayed graft function; diabetes mellitus; ethnicity; female; follow up; graft failure; graft survival; hospitalization; human; human tissue; hypertension; immunosuppressive treatment; kidney donor; kidney graft; major clinical study; male; outcome assessment; overall survival; retrospective study; surgery; vein thrombosis
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Nephrology Dialysis Transplantation
Year:
2022
Document Type:
Article
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