NEUROLOGIC AND RADIOGRAPHIC FINDINGS ASSOCIATED WITH PAEDIATRIC INFLAMMATORY MULTISYSTEM SYNDROME TEMPORALLY ASSOCIATED WITH SARS-COV-2 (PIMS-TS)
Journal of Neurology, Neurosurgery and Psychiatry
; 93(6):96-97, 2022.
Article
in English
| EMBASE | ID: covidwho-1916425
ABSTRACT
Objective Our aim was to report neurological manifestations of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Methods Patients (<18yrs) presenting to Great Ormond Street Hospital between March 1, 2020, and June 21, 2020 fulfilling RCPCH PIMS-TS criteria, were included. Clinical and paraclinical features were retrieved retrospectively from electronic patient records. Results New-onset neurological symptoms/signs were reported in 23/45 (51.1%);headaches (n=16), encephalopathy (n=7), dysarthria/ dysphonia (n=6), hallucinations (n=4), ataxia (n=4), peripheral nerve involvement (n=3), and seizures (n=1). Five (21.7%) patients had CSF analysis;1 patient had 118 leukocytes in CSF. Splenium signal changes were seen in 4/14 patients who had brain MRI. A mild excess of slow activity was found in 10/10 who had an EEG and mild myopathic and neuropathic changes were seen 4/5 who underwent nerve conduction studies and electromyography. Children with neurological involvement had higher peak inflammatory markers and were more likely to be ventilated and require inotropic support in PICU (p<0.05). Conclusions Children with PIMS-TS presented with new neurological symptoms involving both the central and peripheral nervous systems, in the absence of respiratory symptoms. Neurological symptoms were seen more frequently in more severe presentations.
artificial ventilation; ataxia; brain disease; case report; cerebrospinal fluid; child; clinical article; conference abstract; dysarthria; dysphonia; electroencephalogram; electromyography; electronic patient record; female; hallucination; headache; human; human cell; inotropism; leukocyte; male; nerve conduction; neuroimaging; neurologic disease; nuclear magnetic resonance imaging; pediatric multisystem inflammatory syndrome; peripheral nerve; peripheral nervous system; retrospective study; seizure; splenium
Full text:
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Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Journal of Neurology, Neurosurgery and Psychiatry
Year:
2022
Document Type:
Article
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