Statin Intake and All-Cause Mortality among Older Nursing Home Residents.
Gerontology
; 68(4): 407-411, 2022.
Article
in English
| MEDLINE | ID: covidwho-1916487
ABSTRACT
BACKGROUND:
Statins are progressively accepted as being associated with reduced mortality. However, few real-world statin studies have been conducted on statin use in older people and especially the most frail, that is, the nursing home residents.OBJECTIVE:
The aim of this study was to evaluate the impact of statin intake in nursing home residents on all-cause mortality.METHOD:
This is a cross-sectional study of 1,094 older people residing in 6 nursing homes in Flanders (Belgium) between March 1, 2020 and May 30, 2020. We considered all residents who were taking statins for at least 5 days as statin users. All-cause mortality during the 3 months of data collection was the primary outcome. Propensity score overlap-weighted logistic regression models were applied with age, sex, functional status, diabetes, and cardiac failure/ischemia as potential confounders.RESULTS:
185 out of 1,094 residents were on statin therapy (17%). The statin intake was associated with decreased all-cause mortality 4% absolute risk reduction; adjusted odds ratio 0.50; CI 0.31-0.81, p = 0.005.CONCLUSIONS:
The statin intake was associated with decreased all-cause mortality in older people residing in nursing homes. More in-depth studies investigating the potential geroprotector effect of statins in this population are needed.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Qualitative research
/
Randomized controlled trials
Limits:
Aged
/
Humans
Language:
English
Journal:
Gerontology
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS