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Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases.
Custodio, Marco M; Sparks, Jennifer; Long, Timothy E.
  • Custodio MM; Chesapeake Regional Medical Center, 736 Battlefield Blvd. N Chesapeake, VA 23320, USA.
  • Sparks J; Department of Pharmacy Practice, Administration and Research, Marshall University School of Pharmacy, One John Marshall Drive, Huntington WV 24755-0001, USA.
  • Long TE; Department of Pharmaceutical Science and Research, Marshall University School of Pharmacy, One John Marshall, Drive Huntington WV 24755-0001, USA.
Antiinfect Agents ; 20(3)2022 Jun.
Article in English | MEDLINE | ID: covidwho-1917108
ABSTRACT
This article reviews preclinical and clinical studies on the repurposed use of disulfiram (Antabuse) as an antimicrobial agent. Preclinical research covered on the alcohol sobriety aid includes uses as an anti-MRSA agent, a carbapenamase inhibitor, antifungal drug for candidiasis, and treatment for parasitic diseases due to protozoa (e.g., giardiasis, leishmaniasis, malaria) and helminthes (e.g., schistosomiasis, trichuriasis). Past, current, and pending clinical studies on disulfiram as a post-Lyme disease syndrome (PTLDS) therapy, an HIV latency reversal agent, and intervention for COVID-19 infections are also reviewed..
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: 2211352520666220104104747

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: 2211352520666220104104747