The Multifaceted Role of the Ubiquitin Proteasome System in Pathogenesis and Diseases.
Biomolecules
; 12(7)2022 07 01.
Article
in English
| MEDLINE | ID: covidwho-1917275
ABSTRACT
Ubiquitin is a small protein that is conjugated to target proteins to signal a great number of critical biological processes. Impaired ubiquitin signaling and defects in the ubiquitin proteasome system (UPS) surveillance are implicated in many human diseases, including cancer. Characterization of the physiological roles of UPS components and their regulatory mechanisms is therefore vital for the identification of therapeutic targets and the development of tools and paradigms to better understand and treat human diseases. In this Special Issue, we assembled seven original research and review articles to provide insights on the multifaceted role of the UPS in pathogenesis and disease, covering the areas of molecular and cellular mechanisms of UPS enzymes, biochemical and biophysical characterization strategies, drug development, and targeted protein degradation.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Ubiquitin
/
Neoplasms
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Biom12070925
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