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The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela.
Viala, Vincent Louis; Slavov, Svetoslav Nanev; de Lima, Loyze Paola Oliveira; Lima, Alex Ranieri Jeronimo; Ribeiro, Gabriela; Martins, Antonio Jorge; Petry, Bruna; Banho, Cecilia Artico; Barros, Claudia Renata Dos Santos; Moncau, Cristina Tschorny; Moretti, Debora Botequio; de La-Roque, Debora Glenda Lima; Marqueze, Elaine Cristina; Mattos, Elisangela Chicaroni; Costa, Felipe Allan da Silva da; Fukumasu, Heidge; Bernardino, Jardelina de Souza Todao; Souza-Neto, Jayme A; Lesbon, Jessika Cristina Chagas; Kayanoki, Lara Passos; Bernardo, Leandro Lombo; Sacchetto, Lívia; Clemente, Luan Gaspar; Alcantara, Luiz Carlos Júnior; Coutinho, Luiz Lehmann; Marques, Beatriz de Carvalho; Giovanetti, Marta; Nogueira, Maurício Lacerda; Poleti, Mirele Daiana; Assato, Patricia Akemi; Cattony Neto, Pedro De Queiroz; Cassano, Raquel de Lello Rocha Campos; Neto, Raul Machado; Grotto, Rejane Maria Tommasini; Brassaloti, Ricardo Augusto; Kashima, Simone; Covas, Dimas Tadeu; Elias, Maria Carolina; Sampaio, Sandra Coccuzzo.
  • Viala VL; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Slavov SN; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
  • de Lima LPO; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Lima ARJ; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Ribeiro G; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Martins AJ; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Petry B; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba 13418-900, SP, Brazil.
  • Banho CA; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
  • Barros CRDS; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Moncau CT; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba 13418-900, SP, Brazil.
  • Moretti DB; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • de La-Roque DGL; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
  • Marqueze EC; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Mattos EC; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga 13635-900, SP, Brazil.
  • Costa FADSD; Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu 18610-034, SP, Brazil.
  • Fukumasu H; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga 13635-900, SP, Brazil.
  • Bernardino JST; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Souza-Neto JA; School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu 18610-034, SP, Brazil.
  • Lesbon JCC; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga 13635-900, SP, Brazil.
  • Kayanoki LP; Vigilância Epidemiológica de Ilhabela, Ilhabela 11630-000, SP, Brazil.
  • Bernardo LL; Hospital Mario Covas Junior, Ilhabela 11630-000, SP, Brazil.
  • Sacchetto L; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
  • Clemente LG; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba 13418-900, SP, Brazil.
  • Alcantara LCJ; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
  • Coutinho LL; Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil.
  • Marques BC; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba 13418-900, SP, Brazil.
  • Giovanetti M; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
  • Nogueira ML; Reference Laboratory of Flavivirus, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, RJ, Brazil.
  • Poleti MD; Department of Science and Technology for Humans and the Environment, University of Campus Bio-Medico di Roma, 00128 Rome, Italy.
  • Assato PA; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
  • Cattony Neto PQ; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga 13635-900, SP, Brazil.
  • Cassano RLRC; Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu 18610-034, SP, Brazil.
  • Neto RM; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Grotto RMT; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba 13418-900, SP, Brazil.
  • Brassaloti RA; Butantan Institute, São Paulo 05503-900, SP, Brazil.
  • Kashima S; School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu 18610-034, SP, Brazil.
  • Covas DT; Molecular Biology and Applied Biotechnology Laboratory, Clinical Hospital of the Botucatu Medical School, Botucatu 18610-034, SP, Brazil.
  • Elias MC; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba 13418-900, SP, Brazil.
  • Sampaio SC; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Viruses ; 14(7)2022 07 05.
Article in English | MEDLINE | ID: covidwho-1917799
ABSTRACT
Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Variants Limits: Humans Country/Region as subject: South America / Brazil Language: English Year: 2022 Document Type: Article Affiliation country: V14071481

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Variants Limits: Humans Country/Region as subject: South America / Brazil Language: English Year: 2022 Document Type: Article Affiliation country: V14071481