Assessment of the Level of Protein C in Hospitalized Iraqi Patients with COVID-19 and its Correlation with Hematological and Inflammatory Markers
Open Access Macedonian Journal of Medical Sciences
; 10:817-823, 2022.
Article
in English
| EMBASE | ID: covidwho-1917902
ABSTRACT
BACKGROUND:
COVID-19 coagulopathy manifests by elevation of certain marker of active coagulation as fibrinogen and this increment associated with increased markers of inflammations.AIM:
To measure protein C (PC) level in hospitalized patients with COVID-19 and to find a possible correlation with hematological and inflammatory markers. PATIENTS ANDMETHODS:
Seventy-five hospitalized Iraqi adult patients with COVID-19 were included in a descriptive cross-sectional research. PC, D-dimer, and erythrocyte sedimentation rate (ESR) blood samples were collected, and further information was received from patient’s records. Statistical analysis was conducted using SPSS version 23 and Microsoft Office Excel 2019.RESULTS:
Mean age of 75 patients included in the study was 60.13 ± 14.65 years. Sixty-two (62.7%) of patients exhibited neutrophilia, whereas 41 had lymphopenia (54.7%). High ratio of neutrophil/lymphocyte (N/L) was seen in 66 (88.0%), eosinopenia was seen in 46 (61.3%), high lactate dehydrogenase level was seen 68 (90.7%), serum ferritin was high in 66 (88.0%), and high level of C-reactive protein was seen in 68 (90.7%), increased ESR was seen in 69 (92.0%) and high level of D-dimer was seen in 56 (74.7%), while low level of PC was seen in 12 (16.0%) patients. PC had significant negative correlation with prothrombin and partial thromboplastin time but no significant correlation with hematological and inflammatory parameters.CONCLUSION:
COVID-19 coagulopathy is common in majority of patients which include significant changes in WBCs counts, inflammatory markers, PC, and D-dimer levels. Such changes may have a great impact on morbidity and mortality and thus need to be monitored throughout treatment and convalescence.
adult; aged; article; blood clotting disorder; blood sampling; controlled study; convalescence; coronavirus disease 2019; COVID-19-associated coagulopathy; cross-sectional study; data analysis software; drug therapy; eosinopenia; erythrocyte sedimentation rate; female; ferritin blood level; gene expression; human; human cell; human tissue; Iraqi; lymphocyte; lymphocytopenia; major clinical study; male; morbidity; mortality; neutrophil; neutrophilia; partial thromboplastin time; protein expression; C reactive protein; D dimer; endogenous compound; lactate dehydrogenase; protein C; prothrombin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Open Access Macedonian Journal of Medical Sciences
Year:
2022
Document Type:
Article
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