Markers of Coagulation Dysfunction and Inflammation in Diabetic and Non Diabetic COVID-19 Patients- A Retrospective Study
Journal of Clinical and Diagnostic Research
; 16(6):BC12-BC16, 2022.
Article
in English
| EMBASE | ID: covidwho-1918104
ABSTRACT
group and non diabetic control group. Data was presented as Introduction:
Since the end of 2019, a novel Coronavirus percentages for categorical variables and median (interquartile Disease 2019 (COVID-19), declared a pandemic by World Health range) for continuous variables. Chi-square test was used to see Organization (WHO) has ravaged the world. Diabetic patients the association of different qualitative information and Mann-have been reported to be more susceptible to intensive care Whitney U test was used to see the association of quantitative admissions, and deaths due to COVID-19. Diabetes Mellitus data and all p-values were given for justification. A p-value <0.05 (DM) and COVID-19, both associated with chronic and acute was considered statistically significant. inflammation respectively can impact each other in terms ofResults:
The sample included 300 diabetic and 200 non diabetic clinical progression and outcome. Given the novelty of Severe COVID-19 patients. The mean age non diabetic patients (47.5 Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) years) was significantly less as compared to the diabetic group pathogen, there is need to update and increase the limited (54.5 years), p-value <0.001. The serum level of inflammatory evidence on the probability of DM acting as a risk factor and biomarkers, C-Reactive Protein (CRP), ferritin, and markers of influencing disease severity and progression. hypercoagulable state, D-dimer, was found to be significantly highAim:
To compare the markers of inflammation and coagulation (p-value <0.001) in diabetic patients as compared to non diabetic dysfunction between COVID-19 patients with and without DM patients. Diabetics had a poor prognosis with 231 (77%) receiving as co-morbidity and thereby to study the effect DM has on the oxygen as compared to 51 (25.5%) of non diabetic patients. Total prognosis of COVID-19. 173 (57.7%) of diabetic COVID-19 patients had to be shifted to Materials andMethods:
This was a retrospective, observational, ICU, 201 (67%) suffered from post COVID-19 complications and single-centre study, conducted Department of Biochemistry at the mortality rate was higher at 18% in diabetics as compared to Gauhati Medical College and Hospital, Guwahati, Assam, India, 1.5% in non diabetic subjects. from January 2021 to June 2021. Clinical and laboratory dataConclusion:
Diabetic patients are at higher risk of uncontrolled of 500 laboratory confirmed COVID-19 patients were reviewed inflammation and hypercoagulable state which eventually leads in this study. The patients were grouped as diabetic case to deterioration of COVID-19 infection status.
adult; article; Assam; biochemistry; blood clotting disorder; comorbidity; complication; controlled study; coronavirus disease 2019; deterioration; diabetes mellitus; diabetic patient; female; ferritin blood level; glycemic control; human; human tissue; hypercoagulability; infectious agent; inflammation; intensive care; major clinical study; male; medical school; mortality rate; nonhuman; outcome assessment; probability; prognosis; prothrombin time; quantitative analysis; respiratory tract disease; retrospective study; risk factor; Severe acute respiratory syndrome coronavirus 2; biological marker; C reactive protein; D dimer; endogenous compound; ferritin; oxygen
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
Language:
English
Journal:
Journal of Clinical and Diagnostic Research
Year:
2022
Document Type:
Article
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