Mechanism and Clinical Research Progress of Nirmatrelvir Tablets/Ritonavir Tablets: A New Therapeutic Agent for COVID-19
Chinese Pharmaceutical Journal
; 57(10):845-850, 2022.
Article
in Chinese
| EMBASE | ID: covidwho-1918126
ABSTRACT
OBJECTIVE:
To review the mechanism and the clinical research progress of nirmatrelvir tablets/ritonavir tablets(PaxlovidTM), so as to provide references for its rational usage.METHODS:
Literatures related to nirmatrelvir tablets/ritonavir tablets in the official website of US Food and Drug Administration, Pubmed, Embase, CNKI, CBM and Wanfang were systematically searched. The basic information, mechanism of action, pharmacokinetics, pharmacodynamics, clinical efficacy evaluation, safety, drug interaction, drug use in special populations were reviewed. RESULTS ANDCONCLUSIONS:
Nirmatrelvir tablets/ritonavir tablets inhibit the replication of SARS-COV-2 virus by inhibiting the processing of SARS-CoV-2 protein precursor mediated by the main protease. Based on current trial results, nirmatrelvir tablets/ritonavir tablets can significantly reduce hospitalization and mortality rates in adult patients with mild and moderate COVID-19. More research is required to determine whether the drug is appropriate for the clinical treatment of all COVID-19 patients.
adult; article; clinical research; clinical trial; controlled study; coronavirus disease 2019; drug therapy; female; hospitalization; human; male; mortality rate; nonhuman; Severe acute respiratory syndrome coronavirus 2; coronavirus 3C protease; endogenous compound; nirmatrelvir; nirmatrelvir plus ritonavir; protein precursor; ritonavir
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2022
Document Type:
Article
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