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The variant-specific burden of SARS-CoV-2 in Michigan: March 2020 through November 2021.
Petrie, Joshua G; Eisenberg, Marisa C; Lauring, Adam S; Gilbert, Julie; Harrison, Samantha M; DeJonge, Peter M; Martin, Emily T.
  • Petrie JG; Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
  • Eisenberg MC; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Lauring AS; Departments of Internal Medicine and Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
  • Gilbert J; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Harrison SM; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • DeJonge PM; Wisconsin Department of Health Services, Madison, Wisconsin, USA.
  • Martin ET; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
J Med Virol ; 94(11): 5251-5259, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-1919347
ABSTRACT
Accurate estimates of the total burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to inform policy, planning, and response. We sought to quantify SARS-CoV-2 cases, hospitalizations, and deaths by age in Michigan. Coronavirus disease 2019 cases reported to the Michigan Disease Surveillance System were multiplied by age and time-specific adjustment factors to correct for under-detection. Adjustment factors were estimated in a model fit to incidence data and seroprevalence estimates. Age-specific incidence of SARS-CoV-2 hospitalization, death, vaccination, and variant proportions were estimated from publicly available data. We estimated substantial under-detection of infection that varied by age and time. Accounting for under-detection, we estimate the cumulative incidence of infection in Michigan reached 75% by mid-November 2021, and over 87% of Michigan residents were estimated to have had ≥1 vaccination dose and/or previous infection. Comparing pandemic waves, the relative burden among children increased over time. In general, the proportion of cases who were hospitalized or who died decreased over time. Our results highlight the ongoing risk of periods of high SARS-CoV-2 incidence despite widespread prior infection and vaccination. This underscores the need for long-term planning for surveillance, vaccination, and other mitigation measures amidst continued response to the acute pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Child / Humans Country/Region as subject: North America Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27982

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Child / Humans Country/Region as subject: North America Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27982