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Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine.
Torres Crigna, Adriana; Link, Barbara; Samec, Marek; Giordano, Frank A; Kubatka, Peter; Golubnitschaja, Olga.
  • Torres Crigna A; Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
  • Link B; Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
  • Samec M; Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
  • Giordano FA; Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
  • Kubatka P; Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
  • Golubnitschaja O; Predictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
EPMA J ; 12(3): 265-305, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1920184
ABSTRACT
Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly relevant for physical and mental well-being; female and male health; in the modulation of senses, pain, stress reactions and drug sensitivity as well as healing processes, amongst others. Shifted ET-1 homeostasis may influence and predict the development and progression of suboptimal health conditions, metabolic impairments with cascading complications, ageing and related pathologies, cardiovascular diseases, neurodegenerative pathologies, aggressive malignancies, modulating, therefore, individual outcomes of both non-communicable and infectious diseases such as COVID-19. This article provides an in-depth analysis of the involvement of ET-1 and related regulatory pathways in physiological and pathophysiological processes and estimates its capacity as a predictor of ageing and related pathologies,a sensor of lifestyle quality and progression of suboptimal health conditions to diseases for their targeted preventionand as a potent target for cost-effective treatments tailored to the person.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: EPMA J Year: 2021 Document Type: Article Affiliation country: S13167-021-00248-z

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: EPMA J Year: 2021 Document Type: Article Affiliation country: S13167-021-00248-z