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Relationship of anti-SARS-CoV-2 IgG antibodies with Vitamin D and inflammatory markers in COVID-19 patients.
Latifi-Pupovci, Hatixhe; Namani, Sadie; Pajaziti, Artina; Ahmetaj-Shala, Blerina; Ajazaj, Lindita; Kotori, Afrim; Haxhibeqiri, Valdete; Gegaj, Valentin; Bunjaku, Gramoz.
  • Latifi-Pupovci H; University of Pristina, Georg Bush, No.31, 10000, Prishtina, Kosovo.
  • Namani S; University Clinical Center of Kosovo, Pristina, Kosovo.
  • Pajaziti A; University of Pristina, Georg Bush, No.31, 10000, Prishtina, Kosovo. sadie_namani@yahoo.com.
  • Ahmetaj-Shala B; University Clinical Center of Kosovo, Pristina, Kosovo. sadie_namani@yahoo.com.
  • Ajazaj L; University of Pristina, Georg Bush, No.31, 10000, Prishtina, Kosovo.
  • Kotori A; National Heart and Lung Institute, Imperial College London, London, UK.
  • Haxhibeqiri V; University Clinical Center of Kosovo, Pristina, Kosovo.
  • Gegaj V; University for Business and Technology, Pristina, Kosovo.
  • Bunjaku G; University Clinical Center of Kosovo, Pristina, Kosovo.
Sci Rep ; 12(1): 5699, 2022 04 05.
Article in English | MEDLINE | ID: covidwho-1921677
ABSTRACT
Several studies have found an association of COVID-19 disease severity with Vitamin D deficiency and higher levels of anti-SARS-CoV-2 IgGs. The aim of this study was to determine whether levels of Vitamin D and "inflammatory state" influence the magnitude of anti-SARS-CoV-2 IgGs levels in COVID-19 patients. For this purpose, in 67 patients levels of anti-SARS-CoV-2 IgG were measured in week 4 whereas in 52 patients levels of Vitamin D were measured in week 1 after symptom onset. We found that low Vitamin D levels were significantly associated with age and disease severity whereas there was a trend without significance, towards negative correlation of Vitamin D with anti-SARS-CoV-2 IgG. Anti-SARS-CoV-2 IgG were significantly higher in older ages, patients with severe disease, diabetes and those who received corticosteroid and antibiotic therapy. There was a positive correlation of anti-SARS-CoV-2 IgG with IL-6, CRP, LDH, ESR and with percentages of granulocytes. In conclusion, Vitamin D and anti-SARS-CoV-2 IgG share common parameters associated with inflammatory state. However, even though Vitamin D protects against severe forms of COVID-19 it could not directly affect anti-SARS-CoV-2 IgG production.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article