This Week in the Journal

ABSTRACT

In a phase 3 trial, the antibody–drug conjugate trastuzumab deruxtecan resulted in longer progression-free and overall survival than the physician’s choice of chemotherapy among patients with HER2-low breast cancer. see Original Article, N Engl J Med 2022;3879-20 Previous Infection and Vaccination in Covid-19 A study in Qatar assessed the effectiveness of previous infection, vaccination, and both against symptomatic SARS-CoV-2 caused by omicron BA.1 and BA.2 and against severe, critical, or fatal Covid-19. see Original Article, N Engl J Med 2022;38721-34 Brief Report Porcine-to-Human Cardiac Transplantation In this report, a porcine-to-human heart transplantation is described. Most patients with low-risk pulmonary embolism can be treated with oral anticoagulants. see Clinical Practice Audio, N Engl J Med 2022;38745-57 The Vaccine-Hesitant Moment The proliferation of vaccine misinformation and its use for political purposes are placing a large number of people at risk in the Covid-19 pandemic and allowing the pandemic to continue. see Review Article, N Engl J Med 2022;38758-65 Monkeypox Genital Lesions A 31-year-old man presented with a painless genital rash. The midscapular pain was worse at night and lessened with exercise. see Clinical Problem-Solving, N Engl J Med 2022;38767-73 Genetic Modification in Xenotransplantation In a recent case of xenotransplantation, now described in the Journal, a porcine heart was transplanted into a human patient, an advance made possible through genetic alterations in the animal donor. see Editorial, N Engl J Med 2022;38779-82 Tympanostomy Tubes for Recurrent Otitis Media This interactive feature about recurrent acute otitis media in a young child offers a case vignette accompanied by two essays, one supporting insertion of tympanostomy tubes and the other supporting conservative medical management. see Clinical Decisions, N Engl J Med 2022;38783-85 Physicians Spreading Misinformation on Social Media In light of widespread falsehoods about Covid-19 and its treatment and prevention, the American Board of Internal Medicine has informed doctors that disseminating misinformation is grounds for disciplinary sanctions. see Perspective, N Engl J Med 2022;3871-3 Institutionalizing Misinformation A new bill, the Dietary Supplement Listing Act of 2022, would create the impression of reform in the supplement industry while leaving the current lax regulatory framework largely untouched. see Perspective, N Engl J Med 2022;3873-5 The Portal What does it mean for a physician who has long maintained her privileged back channels to finally acquiesce to entering her own electronic medical record — and interacting with her doctors — through the patient portal? see Perspective, N Engl J Med 2022;3875-7 A Call for Antiracist Action The neo-Nazi march on Brigham and Women’s Hospital and attacks on health equity interventions are stark reminders of the obligation of physicians to denounce White supremacism and reaffirm race-conscious antiracism efforts. see Perspective, N Engl J Med 2022;387e1 Decreased Neutralization of Omicron Subvariants In a small study involving 54 participants, omicron subvariants BA.2.12.1, BA.4, and BA.5 of SARS-CoV-2 were more likely to escape neutralizing antibodies induced by both vaccination and previous infection than were the prior omicron subvariants BA.1 and BA.2. see Correspondence, N Engl J Med 2022;38786-88 VITT Recurrence after Covid-19 or Vaccine In 69 patients with vaccine-induced immune thrombotic thrombocytopenia caused by anti–PF4 antibodies, subsequent Covid-19 infection or receipt of an mRNA-based vaccine did not induce VITT recurrence. see Correspondence, N Engl J Med 2022;38788-90