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Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans.
Cho, Alice; Muecksch, Frauke; Wang, Zijun; Ben Tanfous, Tarek; DaSilva, Justin; Raspe, Raphael; Johnson, Brianna; Bednarski, Eva; Ramos, Victor; Schaefer-Babajew, Dennis; Shimeliovich, Irina; Dizon, Juan P; Yao, Kai-Hui; Schmidt, Fabian; Millard, Katrina G; Turroja, Martina; Jankovic, Mila; Oliveira, Thiago Y; Gazumyan, Anna; Gaebler, Christian; Caskey, Marina; Hatziioannou, Theodora; Bieniasz, Paul D; Nussenzweig, Michel C.
  • Cho A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Muecksch F; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Wang Z; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Ben Tanfous T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • DaSilva J; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Raspe R; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Johnson B; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Bednarski E; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Schaefer-Babajew D; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Shimeliovich I; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Dizon JP; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Yao KH; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Schmidt F; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Millard KG; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Turroja M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Jankovic M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Hatziioannou T; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Nussenzweig MC; Howard Hughes Medical Institute, Chevy Chase, MD.
J Exp Med ; 219(8)2022 08 01.
Article in English | MEDLINE | ID: covidwho-1922149
ABSTRACT
The single-dose Ad.26.COV.2 (Janssen) vaccine elicits lower levels of neutralizing antibodies and shows more limited efficacy in protection against infection than either of the two available mRNA vaccines. In addition, Ad.26.COV.2 has been less effective in protection against severe disease during the Omicron surge. Here, we examined the memory B cell response to single-dose Ad.26.COV.2 vaccination. Compared with mRNA vaccines, Ad.26.COV.2 recipients had significantly lower numbers of RBD-specific memory B cells 1.5 or 6 mo after vaccination. Despite the lower numbers, the overall quality of the memory B cell responses appears to be similar, such that memory antibodies elicited by both vaccine types show comparable neutralizing potency against SARS-CoV-2 Wuhan-Hu-1, Delta, and Omicron BA.1 variants. The data help explain why boosting Ad.26.COV.2 vaccine recipients with mRNA vaccines is effective and why the Ad26.COV2.S vaccine can maintain some protective efficacy against severe disease during the Omicron surge.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article