Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape.
Chin Med J (Engl)
; 135(10): 1213-1222, 2022 May 20.
Article
in English
| MEDLINE | ID: covidwho-2190861
ABSTRACT
ABSTRACT The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate. Viral genomic mutations may cause antigenic drift or shift, which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence. Herein, we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Chin Med J (Engl)
Year:
2022
Document Type:
Article
Affiliation country:
CM9.0000000000002158
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