Rapid and high-sensitive LSPR sensor for coronavirus detection
Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XXIII 2022
; 12116, 2022.
Article
in English
| Scopus | ID: covidwho-1923081
ABSTRACT
A rapid, portable, and cost-effective method to detect the infection of SARS-CoV-2 is fundamental toward mitigating the current COVID-19 pandemic. A localized surface plasmon resonance (LSPR) sensor based on human angiotensin-converting enzyme 2 protein (ACE2) functionalized silver nanotriangle array is developed for rapid coronavirus detection. The sensor is validated by SARS-CoV-2 spike RBD protein and CoV NL63 virus with high sensitivity and specificity. A linear shift of the LSPR wavelength and transmission intensity at a fixed wavelength (750 nm) versus the logarithm of the concentration of the spike RBD protein and CoV NL63 is observed. The limits of detection for the spike RBD protein, CoV NL63 in untreated saliva are determined to be 0.38 pM, and 625 PFU/mL, respectively, while the detection time is found to be less than 20 min. Such a LSPR sensor could serve as a potential rapid point-of-care diagnostic platform for COVID-19. © 2022 SPIE
coronavirus detection; coronavirus NL63; localized surface plasmon resonance (LSPR); SARS-CoV-2 spike receptor binding domain; Silver nanotriangle array; Cost effectiveness; Diseases; Proteins; Silver; Surface plasmon resonance; Coronaviruses; Localized surface plasmon resonance; Nanotriangles; Receptor-binding domains; Coronavirus
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Type of study:
Diagnostic study
Language:
English
Journal:
Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XXIII 2022
Year:
2022
Document Type:
Article
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