The Role of Oxidative Imbalance on Pulmonary Diseases

ABSTRACT

[...]W. Jiang et al. demonstrated that endogenous miR-31-5p is a key factor for LPS-induced inflammation and oxidative damage in the lungs, through calcium-binding protein 39- (Cab-39-) dependent inhibition of AMP-activated protein kinase α (AMPKα). Furthermore, they showed that NOX-4-mediated ROS production participates in the TGF-β-induced differentiation of human bronchial smooth muscle cells (HBSMCs) and consequent increase in the synthesis of type I collagen by a mechanism related to activation of the p38MAPK/Akt signaling pathway in a Smad-dependent manner. [...]T. Victoni et al. and L. H. C. Vasconcelos et al. reviewed the role of oxidative imbalance in inflammatory lung diseases and bronchial asthma, respectively.