Association Between the Development of Thrombosis and Worsening of Disease Severity in Patients With Moderate COVID-19 on Admissionã- From the CLOT-COVID Study.
Circ J
; 2022 Jul 01.
Article
in English
| MEDLINE | ID: covidwho-2263851
ABSTRACT
BACKGROUND:
The worsening of coronavirus disease 2019 (COVID-19) severity is a critical issue in current clinical settings and may be associated with the development of thrombosis.MethodsâandâResults:
This study used patient data obtained in the CLOT-COVID study, a retrospective multicenter cohort study. The demographics of patients with moderate COVID-19 on admission with and without worsened severity during hospitalization were compared and predictors were identified. Of 927 patients with moderate COVID-19 on admission, 182 (19.6%) had worsened severity during hospitalization. Patients with worsening of severity were older, more likely to have hypertension, diabetes, heart disease, and active cancer, and more likely to use pharmacological thromboprophylaxis. Patients with worsening of severity had higher D-dimer levels on admission and were more likely to develop thrombosis and major bleeding during hospitalization than those without worsening. Increased age (odds ratio [OR] 1.02, 95% confidence interval [CI] 1.01-1.03, P=0.005), diabetes (OR 1.63, 95% CI 1.11-2.33, P=0.012), D-dimer levels >1.0 µg/mL on admission (OR 2.10, 95% CI 1.45-3.03, P<0.001), and thrombosis (OR 6.28, 95% CI 2.72-14.53, P<0.001) were independently associated with worsening of COVID-19 severity.CONCLUSIONS:
Approximately 20% of patients with moderate COVID-19 had worsened severity during hospitalization. Increased age, diabetes, D-dimer levels >1.0 µg/mL on admission, and the development of thrombosis during hospitalization were significantly associated with worsened COVID-19 severity.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
English
Journal subject:
Vascular Diseases
/
Cardiology
Year:
2022
Document Type:
Article
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