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Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis.
D'Ecclesiis, Oriana; Gavioli, Costanza; Martinoli, Chiara; Raimondi, Sara; Chiocca, Susanna; Miccolo, Claudia; Bossi, Paolo; Cortinovis, Diego; Chiaradonna, Ferdinando; Palorini, Roberta; Faciotti, Federica; Bellerba, Federica; Canova, Stefania; Jemos, Costantino; Salé, Emanuela Omodeo; Gaeta, Aurora; Zerbato, Barbara; Gnagnarella, Patrizia; Gandini, Sara.
  • D'Ecclesiis O; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Gavioli C; Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, Milan, Italy.
  • Martinoli C; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Raimondi S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Chiocca S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Miccolo C; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Bossi P; Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy.
  • Cortinovis D; SC Oncologia Medica, Asst H S Gerardo Monza, Monza, Italy.
  • Chiaradonna F; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
  • Palorini R; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
  • Faciotti F; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Bellerba F; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Canova S; SC Oncologia Medica, Asst H S Gerardo Monza, Monza, Italy.
  • Jemos C; Department of Clinical Pharmacy, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Salé EO; Department of Clinical Pharmacy, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Gaeta A; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Zerbato B; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
  • Gnagnarella P; Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, Milan, Italy.
  • Gandini S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
PLoS One ; 17(7): e0268396, 2022.
Article in English | MEDLINE | ID: covidwho-1923684
ABSTRACT
To assess the evidence on SARS-CoV2 infection and Covid-19 in relation to deficiency and supplementation of vitamin D, we conducted a systematic review up to April 2021. We summarised data from 38 eligible studies, which presented risk estimates for at least one endpoint, including two RCT and 27 cohort-studies 205565 patients with information on 25OHD status and 2022 taking vitamin D supplementation with a total of 1197 admitted to the ICU or who needed invasive mechanical ventilation or intubation and hospital stay, and more than 910 Covid-19 deaths. Primary outcomes were severity and mortality and the main aim was to evaluate the association with vitamin D supplementation. Random effects models showed that supplementation was associated with a significant lower risk of both Covid-19 severe disease (SRR 0.38, 95% CI 0.20-0.72, 6 studies) and mortality (SRR 0.35, 95% CI 0.17-0.70, 8 studies). There were no statistically significant dose differences between studies summary estimates with regular doses remain statistically significant, suggesting that higher doses are not necessary. For patients on vitamin D supplementation, a greater reduction in mortality risk emerged in older individuals and at higher latitudes. Regarding the quality of studies, assessed using the New Castle-Ottawa quality scale, the analysis revealed in most cases no statistically significant differences between low, medium or high quality studies. We found significant associations of vitamin D supplementation with Covid-19, encompassing risks of disease worsening and mortality, especially in seasons characterized by 25OHD deficiency and with not severe patients. Dedicated randomized clinical studies are encouraged to confirm these results.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Traditional medicine Limits: Aged / Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0268396

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Traditional medicine Limits: Aged / Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0268396