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Functional Peptides from SARS-CoV-2 Binding with Cell Membrane: From Molecular Dynamics Simulations to Cell Demonstration.
Hao, Yun; Wu, Rongrong; Wang, Fenghua; Zhang, Liwei; Wang, Zengkai; Song, Xiaolu; Liu, Lei.
  • Hao Y; Institute of Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
  • Wu R; Institute of Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
  • Wang F; Institute of Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
  • Zhang L; Institute of Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
  • Wang Z; Institute of Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
  • Song X; Institute of Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
  • Liu L; Institute of Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
Cells ; 11(11)2022 05 25.
Article in English | MEDLINE | ID: covidwho-1924204
ABSTRACT
Herein, we have verified the interaction between the functional peptides from the SARS-CoV-2 and cell membrane, and we further proved that peptides exhibit little membrane disruption. The specific amino acids (Lys, Ile, Glu, Asn, Gln, etc.) with charge or hydrophobic residues play a significant role during the functional-peptide binding to membrane. The findings could provide the hints related to viral infection and also might pave the way for development of new materials based on peptides with membrane-binding activity, which would enable functional peptides further as peptide adjuvants, in order to help deliver the cancer drug into tumor cells for the efficient tumor therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Molecular Dynamics Simulation / COVID-19 Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11111738

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Molecular Dynamics Simulation / COVID-19 Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11111738