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COVID-19 and neurodegenerative diseases.
Fu, Y-W; Xu, H-S; Liu, S-J.
  • Fu YW; Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine & Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Medical University, Shuangyong Road, Nanning, P.R. China. heming_liu@163.com.
Eur Rev Med Pharmacol Sci ; 26(12): 4535-4544, 2022 06.
Article in English | MEDLINE | ID: covidwho-2230121
ABSTRACT

OBJECTIVE:

The pandemic of Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues, and SARS-CoV-2 variants continue to emerge. In addition to typical fever and respiratory symptoms, many patients with COVID-19 experience a variety of neurological complications. In this review, we analyzed and reviewed the current status and possible mechanisms between COVID-19 and several typical neurodegenerative diseases, particularly Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, hoping to propose the potential direction of further research and concern. MATERIALS AND

METHODS:

Electronic literature search of the databases (Medline/PubMed, Web of Science, and Google Scholar). The keywords used were COVID-19, SARS-CoV-2, neurodegenerative disease, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The retrieved relevant articles were reviewed and critically analyzed.

RESULTS:

SARS-CoV-2 is a highly neuroinvasive neurotropic virus that invades cells through angiotensin-converting enzyme 2 (ACE2) receptor-driven pathway. SARS-CoV-2 neuroinvasion, neuroinflammation, and blood-brain barrier (BBB) dysfunction may contribute to the pathogenesis of neurodegenerative diseases.

CONCLUSIONS:

Some patients with neurodegenerative diseases have already shown more susceptibility to SARS-CoV-2 infection and significantly higher mortality due to the elderly population with underlying diseases. Moreover, SARS-CoV-2 could cause damage to the central nervous system (CNS) that may substantially increase the incidence of neurodegenerative diseases and accelerate the progression of them.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / Neurodegenerative Diseases / Alzheimer Disease / COVID-19 / Amyotrophic Lateral Sclerosis Type of study: Observational study / Reviews Topics: Long Covid / Variants Limits: Aged / Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / Neurodegenerative Diseases / Alzheimer Disease / COVID-19 / Amyotrophic Lateral Sclerosis Type of study: Observational study / Reviews Topics: Long Covid / Variants Limits: Aged / Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2022 Document Type: Article