Phenotyping the Chronic Neurological Sequelae of Acute SARS-CoV-2 Infections
Neurology
; 98(18 SUPPL), 2022.
Article
in English
| EMBASE | ID: covidwho-1925494
ABSTRACT
Objective:
To phenotype the neurological dysfunction in post-acute sequelae SARS-CoV-2 infection.Background:
Neurological complications of SARS-CoV-2 infection can arise acutely but can also emerge and persist weeks and months after acute infection. These symptoms can affect up to 80% of those with post-acute sequelae SARS-CoV-2 infection (PASC). The University of Pennsylvania Neuro-COVID Clinic (PNCC) was established to provide care for patients with PASC and to obtain standardized clinical metrics to better define the neurological complications attributed to PASC. Design/Methods:
Retrospective analysis of charts from the first 94 patients seen at the PNCC. Demographics as well as standardized clinical histories were reviewed. Standardized cognitive testing including the Montreal Cognitive Assessment (MOCA version 8.2), Trails A and B, and digit span (forward and reverse) were performed and analyzed with summary statistics.Results:
Mean age of this patient population was 50 years (range 21 - 75yrs) and 67% were female. 30% of patients were admitted to inpatient care during their acute infection (4% required ICU level care). The average time from acute infection to first visit at the PNCC was 234 days (range 40 - 509 days). The most frequent primary neurological complaint was brain fog (68%) and 91% of patients endorsed some level of brain fog. Abnormal testing (> 4 missed points) on MOCA testing was measured in 39% of patients. Abnormal testing on Trails B (below the age-adjusted 9 percentile) was measured in 16% of patients.Conclusions:
Neurological manifestations of PASC are common even in non-hospitalized patients and brain fog is a frequent symptom. Discrepancies between subjective experience and standardized cognitive testing suggest a multifactorial cause to brain fog in PASC. Co-occurrence of mood symptoms, poor sleep, and medication side effects may exacerbate more direct effects of COVID-19. The long-term trajectory of neurological symptoms in PASC will be determined with longitudinal follow-up of this patient cohort. th.
adult; adverse drug reaction; aged; clouding of consciousness; cohort analysis; complication; conference abstract; coronavirus disease 2019; demographics; female; follow up; hospital patient; human; major clinical study; male; middle aged; Montreal cognitive assessment; mood; neurologic disease; neurological complication; Pennsylvania; phenotype; retrospective study; side effect; sleep
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Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Long Covid
Language:
English
Journal:
Neurology
Year:
2022
Document Type:
Article
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