Apparently healthy adults with high serum gamma-glutamyl transferase levels are at increased risk of asthma development in the near future: a Korean nationwide cohort study
European Review for Medical and Pharmacological Sciences
; 26(11):3958-3966, 2022.
Article
in English
| Web of Science | ID: covidwho-1925508
ABSTRACT
OBJECTIVE:
Serum gamma-glutamyl transferase (GGT). an indicator of oxidative stress and/or a chronic inflammatory process, is associated with the levels of leukotrienes and other inflammatory mediators that play a critical role in the pathogenesis of asthma. This study aimed at investigating whether apparently healthy subjects with higher serum GGT levels at a national health check-up are at an increased risk of developing asthma in the near future. PATIENTS ANDMETHODS:
We analyzed 564.213 Korean adults, aged 20-80 years who underwent a national general health examination, including measurement of baseline serum GGT between 2003 and 2015. using data from a largescale representative cohort of the Korean population. Data were analyzed using a Cox proportional hazards regression analysis.RESULTS:
In total, 516,956 participants were included in the final analysis. During the mean follow-up period of 8 years (standard deviation, 4.0), 7,439 incident asthma events occurred. We then classified the male and female participants according to quartiles of blood GGT levels (males <= 20, 21-30, 31-51, and >= 52 IU/L females <= 12. 13-16, 17-22, and >= 23 IU/L. respectively). The adjusted hazard ratio (aHR) for incident asthma was significantly greater for subjects in the highest GGT quartile than for those in the lowest GGT quartile (aHR, 1.47 95% confidence intervals, 1.36-1.59). Further, there was a significant linear trend across quartiles with regard to asthma (p(trend)<0 .001). We estimated the optimal cut-off values (using the minimum p-value approach) as 35IU/L for the total population. 35 IU/L for males, and 36 IU/L for females, respectively.CONCLUSIONS:
Clinicians should be aware of the risk of incident asthma in healthy subjects with elevated GGT levels. Our findings advance our understanding of asthma pathogenesis.
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Collection:
Databases of international organizations
Database:
Web of Science
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
English
Journal:
European Review for Medical and Pharmacological Sciences
Year:
2022
Document Type:
Article
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