COVID-19 vaccination-triggered cluster headache episodes with frequent attacks.
Cephalalgia
; 42(13): 1420-1424, 2022 11.
Article
in English
| MEDLINE | ID: covidwho-1927983
ABSTRACT
BACKGROUND:
The pathophysiology of cluster headache and how cluster episodes are triggered, are still poorly understood. Recurrent inflammation of the trigeminovascular system has been hypothesized. It was noted that some long-term attack-free cluster headache patients suddenly developed a new cluster episode shortly after COVID-19 vaccination.METHODS:
Cases are described from patients with cluster headache who reported a new cluster episode within days after COVID-19 vaccination. All cases were seen in a tertiary university referral center and a general hospital in the Netherlands between March 2021 and December 2021, when the first COVID-19 vaccinations were carried out in The Netherlands. Clinical characteristics of the previous and new cluster episodes, and time between the onset of a new cluster episode and a previous COVID-19 vaccination were reported.RESULTS:
We report seven patients with cluster headache, who had been attack-free for a long time, in whom a new cluster episode occurred within a few days after a COVID-19 vaccination.INTERPRETATION:
COVID-19 vaccinations may trigger new cluster episodes in patients with cluster headache, possibly by activating a pro-inflammatory state of the trigeminocervical complex. COVID-19 vaccinations may also exacerbate other neuroinflammatory conditions. .Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cluster Headache
/
COVID-19 Vaccines
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
Cephalalgia
Year:
2022
Document Type:
Article
Affiliation country:
03331024221113207
Similar
MEDLINE
...
LILACS
LIS