Your browser doesn't support javascript.
Encephalitis with status epilepticus and stroke as complications of non-severe COVID-19 in a young female patient: a case report.
Koh, Seungyon; Kim, Yoon Seob; Kim, Min Hye; Choi, Young Hwa; Choi, Jun Young; Kim, Tae-Joon.
  • Koh S; Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
  • Kim YS; Department of Brain Science, Ajou University School of Medicine, Suwon, Republic of Korea.
  • Kim MH; Department of Neurology, Ajou University Hospital, Suwon, Republic of Korea.
  • Choi YH; Department of Neurology, Ajou University Hospital, Suwon, Republic of Korea.
  • Choi JY; Department of Infectious Disease, Ajou University School of Medicine, Suwon, Republic of Korea.
  • Kim TJ; Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
BMC Neurol ; 22(1): 253, 2022 Jul 11.
Article in English | MEDLINE | ID: covidwho-1928163
ABSTRACT

BACKGROUND:

Neurological manifestations of COVID-19 are thought to be associated with the disease severity of COVID-19 and poor clinical outcomes. Dysregulated immune responses are considered to be mediating such complications. Our case illustrates multiple critical neurological complications simultaneously developed in a patient with non-severe COVID-19 and successful recovery with a multifaceted therapeutic approach. The cerebrospinal fluid (CSF) interleukin-6 (IL-6) level was temporally correlated with the clinical severity of the status epilepticus in our patient, suggesting a causal relationship. CASE PRESENTATION A previously healthy 20-year-old female patient presented with a first-onset seizure. Concomitant non-severe COVID-19 pneumonia was diagnosed. CSF study showed lymphocytic pleocytosis with elevated IL-6 levels in CSF. During hospitalization under the diagnosis of autoimmune encephalitis, status epilepticus developed, and the seizure frequency was temporally correlated with the CSF IL-6 level. Furthermore, a new embolic stroke developed without a significant cardioembolic source. Contrary to the exacerbated COVID-19-associated neurological complications, COVID-19 pneumonia was cleared entirely. After treatment with antiseizure medications, antithrombotics, antiviral agents, and immunotherapy, the patient was discharged with near-complete recovery.

CONCLUSION:

Active serological, and radiological evaluation can be helpful even in non-severe COVID-19, and multidimensional treatment strategies, including immunotherapy, can successfully reverse the neurological complication.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Status Epilepticus / Stroke / Encephalitis / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Young adult Language: English Journal: BMC Neurol Journal subject: Neurology Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Status Epilepticus / Stroke / Encephalitis / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Young adult Language: English Journal: BMC Neurol Journal subject: Neurology Year: 2022 Document Type: Article