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Evolution of the Clinical Profile and Outcomes of Unvaccinated Patients Affected by Critical COVID-19 Pneumonia from the Pre-Vaccination to the Post-Vaccination Waves in Italy.
Calabrese, Cecilia; Annunziata, Anna; Mariniello, Domenica Francesca; Coppola, Antonietta; Mirizzi, Angela Irene; Simioli, Francesca; Pelaia, Corrado; Atripaldi, Lidia; Pugliese, Gaia; Guarino, Salvatore; Fiorentino, Giuseppe.
  • Calabrese C; Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Annunziata A; Department of Intensive Care, A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Mariniello DF; Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Coppola A; Department of Intensive Care, A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Mirizzi AI; Department of Intensive Care, A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Simioli F; Department of Intensive Care, A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Pelaia C; Respiratory Medicine Unit, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
  • Atripaldi L; Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Pugliese G; Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Guarino S; Department of Radiology, Monaldi Hospital, A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
  • Fiorentino G; Department of Intensive Care, A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
Pathogens ; 11(7)2022 Jul 14.
Article in English | MEDLINE | ID: covidwho-1928621
ABSTRACT
The vaccination campaign and the new SARS-CoV-2 variants may have changed the clinical profile and outcomes of patients admitted to sub-intensive unit care. We conducted a retrospective study aimed to compare the clinical and radiological features of unvaccinated critical COVID-19 patients hospitalized during the last pandemic wave (December 2021-February 2022, No-Vax group) and before starting the vaccination campaign (March-December 2020, Pre-Vax group). The No-Vax group was also compared with vaccinated patients of the same pandemic wave (Vax group). With respect to the Pre-Vax group, the No-Vax group contained a higher percentage of smokers (p = 0.0007) and a lower prevalence of males (p = 0.0003). At admission, the No-Vax patients showed both a higher CT score of pneumonia and a worse severe respiratory failure (p < 0.0001). In the No-Vax group, a higher percentage of deaths occurred, though this was not significant. In comparison with the No-Vax group, the Vax patients were older (p = 0.0097), with a higher Charlson comorbidity index (p < 0.0001) and a significantly lower HRCT score (p = 0.0015). The percentage of deaths was not different between the two groups. The No-Vax patients showed a more severe disease in comparison with the Pre-Vax patients, and were younger and had fewer comorbidities than the Vax patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Pathogens11070793

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Pathogens11070793