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COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study.
Valladares-Garrido, Mario J; Zeña-Ñañez, Sandra; Peralta, C Ichiro; Puicón-Suárez, Jacqueline B; Díaz-Vélez, Cristian; Failoc-Rojas, Virgilio E.
  • Valladares-Garrido MJ; Vicerrectorado de Investigación, Universidad Norbert Wiener, Lima 15046, Peru.
  • Zeña-Ñañez S; Hospital Regional Lambayeque, Chiclayo 14012, Peru.
  • Peralta CI; Instituto de Evaluación de Tecnologías en Salud e Investigación-IETSI, EsSalud, Lima 15072, Peru.
  • Puicón-Suárez JB; School of Medicine, Universidad Continental, Huancayo 12001, Peru.
  • Díaz-Vélez C; School of Medicine, Universidad Nacional Federico Villarreal, Lima 15088, Peru.
  • Failoc-Rojas VE; Sociedad Científica de Estudiantes de Medicina, Universidad Nacional Pedro Ruiz Gallo, Lambayeque 14013, Peru.
Vaccines (Basel) ; 10(5)2022 May 20.
Article in English | MEDLINE | ID: covidwho-1928680
ABSTRACT
COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admission, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28-0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Country/Region as subject: South America / Peru Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10050812

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Country/Region as subject: South America / Peru Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10050812