Variation of SARS-CoV-2 spike protein and its effects on neutralization sensitivity
Chinese Journal of Microbiology and Immunology (China)
; 42(1):1-10, 2022.
Article
in Chinese
| EMBASE | ID: covidwho-1928716
ABSTRACT
The COVID-19 epidemic that occurred at the end of 2019 spreads rapidly to all parts of the world, putting the global public health system to a severe test. With the continuation of the epidemic, SARS-CoV-2 variants are constantly emerging. In particular, the mutation of the spike protein can cause changes in the infectivity and antigenicity of the virus, resulting in an increase in the infectivity and a decline in the protective efficacy of existing vaccines, and even the replacement of epidemic strains. This is also one of the reasons why the epidemic has not been effectively controlled so far. Nowadays, the main circulating variants have changed their characteristics to a certain extent, and the neutralization sensitivity of some variants to neutralizing monoclonal antibodies, immune sera and convalescent sera has decreased to a certain extent compared with the original strains. The emergence of variants is not only related to the characteristics of the virus itself, but also to the changes of transmission host and the chronic infection in people with deficient immunity. The emerging variants should be closely monitored, and their functional characteristics should be systematically studied so as to provide data for vaccine research and development and the designation of immunization strategies.
antigenicity; article; chronic infection; controlled study; coronavirus disease 2019; epidemic; genetic susceptibility; human; immunization; nonhuman; protein function; public health; Severe acute respiratory syndrome coronavirus 2; virus transmission; antiserum; convalescent serum; endogenous compound; monoclonal antibody; neutralizing antibody; vaccine; virus spike protein
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Language:
Chinese
Journal:
Chinese Journal of Microbiology and Immunology (China)
Year:
2022
Document Type:
Article
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