Progress on the protective effect of heme oxygenase-1 in viral infection
Yaoxue Xuebao
; 57(6):1574-1583, 2022.
Article
in Chinese
| EMBASE | ID: covidwho-1928934
ABSTRACT
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that catalyzes the conversion of heme to CO, biliverdin, and iron, which together protect cells from oxidative and inflammatory damage and play an important role in maintaining cell homeostasis. In recent years, HO-1 has also been found to have antiviral biological effects, and the induced expression of HO-1 inhibits the replication of various viruses such as hepatitis C virus, hepatitis B virus, human immunodeficiency virus, dengue virus, ebolavirus, influenza A virus, Zika virus, severe acute respiratory syndrome coronavirus 2, human respiratory syncytial virus, hepatitis A virus and enterovirus 71. The inhibitory effect of HO-1 on these viruses involves three mechanisms, including direct inhibition of virus replication by HO-1 and its downstream products, enhancement of type I interferon responses in host cell, and attenuation of inflammatory damage caused by viral infection. This review focuses on the recent advances in the antiviral effect of HO-1 and its mechanism, which is expected to provide evidence for HO-1 as a potential target for antiviral therapy.
antiviral activity; antiviral therapy; article; catalysis; Dengue virus; Ebolavirus; Enterovirus A71; gene expression; Hepatitis A virus; Hepatitis B virus; Hepatitis C virus; homeostasis; host cell; human; Human immunodeficiency virus; Human respiratory syncytial virus; immune response; Influenza A virus; injury; nonhuman; oxidation; oxidative stress; protein expression; protein function; Severe acute respiratory syndrome coronavirus 2; virus infection; virus replication; Zika virus; antivirus agent; biliverdin; endogenous compound; heme; heme oxygenase 1; interferon; iron
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Language:
Chinese
Journal:
Yaoxue Xuebao
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS