Factors Associated with Intensive Care Unit Admission and Mortality in COVID-19 Infection during May-August 2020 Period
Klimik Dergisi
; 35(2):68-73, 2022.
Article
in Turkish
| EMBASE | ID: covidwho-1929120
ABSTRACT
Objective:
COVID-19 infection causes severe pneumonia and multi-organ failure in adults, increases morbidity and mortality. Our study aimed to determine the factors affecting intensive care unit admission and mortality in hospitalized COVID-19 patients.Methods:
The demographic, clinical, and laboratory data of hospitalized patients due to COVID-19 between May 1, 2020 and August 1, 2020 were evaluated retrospectively. Patients who were admitted to the intensive care unit or died during follow-up were included in the study group, and patients who were followed in the inpatient settings and sur-vived consisted the control group. The data obtained at the time of hospitalization were evaluated statistically.Results:
A total of 473 patients were included in the study. The median age of the patients was 53 years (40-68 years), and 269 (56.9%) were male. During the follow-up, 93(19.7%) patients were admitted to the intensive care unit (ICU). Of the 468 patients for whom follow-up data were available, 62(13.2%) patients died. Patients with older age and comorbid diseases had higher ICU admission and mortality rates (p<0.001 and p<0.001). ICU admission rate was higher in patients with cough (p=0.002), myalgia (p=0.016), and dyspnea (p<0.001) during hospital admission. At the same time, dyspnea was more common in patients who died (p<0.001), and myalgia was more common in surviving patients (p=0.020). Laboratory values associated with both ICU admission and mortality were glucose (p<0.001, p<0.001), AST (p<0.001, p<0.001), serum creatinine (p<0.001, p<0.001), direct bilirubin (p<0.001, p=0.009), albumin (p<0.001, p<0.001), CRP (C-reactive protein) (p<0.001, p<0.001), procalcitonin (p<0.001, p<0.001), leukocyte count (p<0.001, p<0.001), lymphocyte count (p<0.001, p<0.001), neutrophil count (p=0.007, p<0.001), hemoglobin (p<0.001, p<0.001), troponin (p<0.001, p<0.001), D-dimer (p<0.001, p<0.001), ferritin (p<0.001, p<0.001), prothrombin time (p<0.001, p<0.001) and INR (international normalized ratio) (p<0.001, p<0.001) levels.Conclusions:
Determining the parameters that define high-risk COVID-19 infected patients in the early period can contribute to reduce ICU admissions and mortality by improving patient management and resource utilization in hospitals.
adult; aged; article; aspartate aminotransferase level; controlled study; coronavirus disease 2019; coughing; creatinine blood level; demography; dyspnea; female; ferritin blood level; follow up; hospital admission; hospital patient; hospitalization; human; human tissue; intensive care unit; international normalized ratio; leukocyte count; lymphocyte count; major clinical study; male; middle aged; mortality; mortality rate; myalgia; neutrophil count; patient care; prothrombin time; retrospective study; risk assessment; albumin; bilirubin glucuronide; C reactive protein; D dimer; endogenous compound; ferritin; glucose; hemoglobin; procalcitonin; troponin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
Turkish
Journal:
Klimik Dergisi
Year:
2022
Document Type:
Article
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