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Ultraefficiently Calming Cytokine Storm Using Ti3C2T x MXene.
Wang, Tianyi; Sun, Xiaoyu; Guo, Xin; Zhang, Jinqiang; Yang, Jian; Tao, Shouxuan; Guan, Jun; Zhou, Lin; Han, Jie; Wang, Chengyin; Yao, Hang; Wang, Guoxiu.
  • Wang T; Faculty of Science University of Technology Sydney Sydney NSW 2007 Australia.
  • Sun X; School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu Province 225002 P. R. China.
  • Guo X; Faculty of Science University of Technology Sydney Sydney NSW 2007 Australia.
  • Zhang J; Faculty of Science University of Technology Sydney Sydney NSW 2007 Australia.
  • Yang J; School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu Province 225002 P. R. China.
  • Tao S; School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu Province 225002 P. R. China.
  • Guan J; Clinical Medical College Northern Jiangsu People's Hospital Yangzhou University Yangzhou Jiangsu Province 225009 P. R. China.
  • Zhou L; Clinical Medical College Northern Jiangsu People's Hospital Yangzhou University Yangzhou Jiangsu Province 225009 P. R. China.
  • Han J; School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu Province 225002 P. R. China.
  • Wang C; School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu Province 225002 P. R. China.
  • Yao H; School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu Province 225002 P. R. China.
  • Wang G; Faculty of Science University of Technology Sydney Sydney NSW 2007 Australia.
Small Methods ; 5(5): 2001108, 2021 05 12.
Article in English | MEDLINE | ID: covidwho-2286155
ABSTRACT
During the global outbreak of COVID-19 pandemic, "cytokine storm" conditions are regarded as the fatal step resulting in most mortality. Hemoperfusion is widely used to remove cytokines from the blood of severely ill patients to prevent uncontrolled inflammation induced by a cytokine storm. This article discoveres, for the first time, that 2D Ti3C2T x MXene sheet demonstrates an ultrahigh removal capability for typical cytokine interleukin-6. In particular, MXene shows a 13.4 times higher removal efficiency over traditional activated carbon absorbents. Molecular-level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin-6 molecules, which is different from activated carbon absorbents. MXene sheet also demonstrates excellent blood compatibility without any deleterious side influence on the composition of human blood. This work can open a new avenue to use MXene sheets as an ultraefficient hemoperfusion absorbent to eliminate the cytokine storm syndrome in treatment of severe COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / COVID-19 Limits: Humans Language: English Journal: Small Methods Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / COVID-19 Limits: Humans Language: English Journal: Small Methods Year: 2021 Document Type: Article