Occurrence and outcomes of possible superadded infections in older adults with COVID-19-cohort study.
Eur Geriatr Med
; 13(5): 1161-1167, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-1930646
ABSTRACT
PURPOSE:
Current guidance discourages use of antibiotics in COVID-19. However, in older adults, superadded infection may be common and require treatment. Our aim was to investigate the occurrence and outcomes from possible superadded infections, occurring within 2 weeks of hospitalization, in older adults with COVID-19.METHODS:
This was a single centre, observational cohort study. We collected data from patients admitted to older adult wards who had tested positive for the Sars-CoV-2 virus on viral PCR between 1st October and 1st December 2020. The primary outcome was inpatient death occurring within 90 days of COVID-19 diagnosis. The secondary outcome was length of stay in hospital. Associations were described using univariable and multivariable models, and time to event data.RESULTS:
Of 266 patients with COVID-19, 43% (115) had evidence of superadded infections (91 with positive bacterial cultures and 36 instances of radiological lobar consolidation). Patients with superadded infections were more likely to die (45.2 versus 30.7%, p = 0.020) and had an increased length of stay (23 versus 18 days, p = 0.026).CONCLUSIONS:
Recommendations to avoid antibiotics in COVID-19 may not be applicable to an older adult population. Assessing for possible superadded infections is warranted in this group.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Superinfection
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Aged
/
Humans
Language:
English
Journal:
Eur Geriatr Med
Year:
2022
Document Type:
Article
Affiliation country:
S41999-022-00675-9
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