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Trained immunity in viral infections, Alzheimer's disease and multiple sclerosis: A convergence in type I interferon signalling and IFNß-1a.
Vavougios, George D; Mavridis, Theodore; Artemiadis, Artemios; Krogfelt, Karen A; Hadjigeorgiou, Georgios.
  • Vavougios GD; Department Neurology, University of Cyprus, Lefkosia, Cyprus; Department of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa 41500, Greece. Electronic address: vavougyios.georgios@ucy.ac.cy.
  • Mavridis T; 1st Neurology Department, Eginition Hospital, Medical School, National & Kapodistrian University of Athens, Greece.
  • Artemiadis A; Department Neurology, University of Cyprus, Lefkosia, Cyprus.
  • Krogfelt KA; Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece; Department of Molecular and Medical Biology, Centre for Mathematical Modeling - Human Health and Disease, PandemiX Center, Universitetsvej 1, 28A.1, DK-4000 Roskilde, Denmark.
  • Hadjigeorgiou G; Department Neurology, University of Cyprus, Lefkosia, Cyprus. Electronic address: hadjigeorgiou.georgios@ucy.ac.cy.
Biochim Biophys Acta Mol Basis Dis ; 1868(9): 166430, 2022 09 01.
Article in English | MEDLINE | ID: covidwho-1930739
ABSTRACT
Type I interferon (IFN-I) signalling represents a major target for modulation in a virus' bid for latency. IFN-I perturbations are also present in such as Alzheimer's disease (AD) and multiple sclerosis (MS), where viral infections are known to increase symptomatic burden. IFN-I modulation such as via IFNß-1a, an established MS treatment, has been researched to a limited extent to both AD and COVID-19. In this mini review, we present emerging research on trained immunity as a pathogenetic basis for Alzheimer's disease and the emerging context for IFNß-1a repositioning, via mechanisms shared with multiple sclerosis and induced by viral infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Alzheimer Disease / COVID-19 / Multiple Sclerosis Topics: Long Covid Limits: Humans Language: English Journal: Biochim Biophys Acta Mol Basis Dis Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Alzheimer Disease / COVID-19 / Multiple Sclerosis Topics: Long Covid Limits: Humans Language: English Journal: Biochim Biophys Acta Mol Basis Dis Year: 2022 Document Type: Article