Healthy lifestyle changes favourably affect common carotid intima-media thickness: the Healthy Lifestyle Community Programme (cohort 2).
J Nutr Sci
; 11: e47, 2022.
Article
in English
| MEDLINE | ID: covidwho-1931256
ABSTRACT
Common carotid intima-media thickness (ccIMT) progression is a risk marker for cardiovascular disease (CVD), whereas healthy lifestyle habits are associated with lower ccIMT. The objective of the present study was to test whether a healthy lifestyle intervention can beneficially affect ccIMT progression. A community-based non-randomised, controlled lifestyle intervention was conducted, focusing on a predominantly plant-based diet (strongest emphasis), physical activity, stress management and social health. Assessments of ccIMT were made at baseline, 6 months and 1 year. Participants had an average age of 57 years and were recruited from the general population in rural northwest Germany (intervention n 114; control n 87). From baseline to 1 year, mean ccIMT significantly increased in both the intervention (0â
026 [95 % CI 0â
012, 0â
039] mm) and control group (0â
045 [95 % CI 0â
033, 0â
056] mm). The 1-year trajectory of mean ccIMT was lower in the intervention group (P = 0â
022; adjusted for baseline). In a subgroup analysis with participants with high baseline mean ccIMT (≥0â
800 mm), mean ccIMT non-significantly decreased in the intervention group (-0â
016 [95 % CI -0â
050, 0â
017] mm; n 18) and significantly increased in the control group (0â
065 [95 % CI 0â
033, 0â
096] mm; n 12). In the subgroup, the 1-year trajectory of mean ccIMT was significantly lower in the intervention group (between-group difference -0â
051 [95 % CI -0â
075, -0â
027] mm; P < 0â
001; adjusted for baseline). The results indicate that healthy lifestyle changes may beneficially affect ccIMT within 1 year, particularly if baseline ccIMT is high.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Carotid Intima-Media Thickness
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
/
Middle aged
Language:
English
Journal:
J Nutr Sci
Year:
2022
Document Type:
Article
Affiliation country:
Jns.2022.46
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