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Healthy lifestyle changes favourably affect common carotid intima-media thickness: the Healthy Lifestyle Community Programme (cohort 2).
Koeder, Christian; Husain, Sarah; Kranz, Ragna-Marie; Anand, Corinna; Alzughayyar, Dima; Schoch, Nora; Hahn, Andreas; Englert, Heike.
  • Koeder C; Institute of Food Science and Human Nutrition, Leibniz University Hanover, Am Kleinen Felde 30, 30167 Hanover, Germany.
  • Husain S; Department of Nutrition, University of Applied Sciences Münster, Corrensstr. 25, 48149 Münster, Germany.
  • Kranz RM; Department of Nutrition, University of Applied Sciences Münster, Corrensstr. 25, 48149 Münster, Germany.
  • Anand C; Department of Nutrition, University of Applied Sciences Münster, Corrensstr. 25, 48149 Münster, Germany.
  • Alzughayyar D; Department of Nutrition, University of Applied Sciences Münster, Corrensstr. 25, 48149 Münster, Germany.
  • Schoch N; Department of Nutrition, University of Applied Sciences Münster, Corrensstr. 25, 48149 Münster, Germany.
  • Hahn A; Department of Nutrition, University of Applied Sciences Münster, Corrensstr. 25, 48149 Münster, Germany.
  • Englert H; Institute of Food Science and Human Nutrition, Leibniz University Hanover, Am Kleinen Felde 30, 30167 Hanover, Germany.
J Nutr Sci ; 11: e47, 2022.
Article in English | MEDLINE | ID: covidwho-1931256
ABSTRACT
Common carotid intima-media thickness (ccIMT) progression is a risk marker for cardiovascular disease (CVD), whereas healthy lifestyle habits are associated with lower ccIMT. The objective of the present study was to test whether a healthy lifestyle intervention can beneficially affect ccIMT progression. A community-based non-randomised, controlled lifestyle intervention was conducted, focusing on a predominantly plant-based diet (strongest emphasis), physical activity, stress management and social health. Assessments of ccIMT were made at baseline, 6 months and 1 year. Participants had an average age of 57 years and were recruited from the general population in rural northwest Germany (intervention n 114; control n 87). From baseline to 1 year, mean ccIMT significantly increased in both the intervention (0⋅026 [95 % CI 0⋅012, 0⋅039] mm) and control group (0⋅045 [95 % CI 0⋅033, 0⋅056] mm). The 1-year trajectory of mean ccIMT was lower in the intervention group (P = 0⋅022; adjusted for baseline). In a subgroup analysis with participants with high baseline mean ccIMT (≥0⋅800 mm), mean ccIMT non-significantly decreased in the intervention group (-0⋅016 [95 % CI -0⋅050, 0⋅017] mm; n 18) and significantly increased in the control group (0⋅065 [95 % CI 0⋅033, 0⋅096] mm; n 12). In the subgroup, the 1-year trajectory of mean ccIMT was significantly lower in the intervention group (between-group difference -0⋅051 [95 % CI -0⋅075, -0⋅027] mm; P < 0⋅001; adjusted for baseline). The results indicate that healthy lifestyle changes may beneficially affect ccIMT within 1 year, particularly if baseline ccIMT is high.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Carotid Intima-Media Thickness Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Middle aged Language: English Journal: J Nutr Sci Year: 2022 Document Type: Article Affiliation country: Jns.2022.46

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Carotid Intima-Media Thickness Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Middle aged Language: English Journal: J Nutr Sci Year: 2022 Document Type: Article Affiliation country: Jns.2022.46