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Age-Related Dynamics of Serum Anti-Spike IgG Ab After the Third Dose of BNT162b2 Vaccine in a Naive Health Care Workers Population.
Salerno, Gerardo; Gentile, Giovanna; De Luca, Ottavia; Costanzi, Giuseppe; Cirelli, Gloria; Di Simone Di Giuseppe, Barbara; Marcellini, Laura; Anibaldi, Paolo; Marcolongo, Adriano; Simmaco, Maurizio; Borro, Marina.
  • Salerno G; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.
  • Gentile G; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy.
  • De Luca O; Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.
  • Costanzi G; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy.
  • Cirelli G; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy.
  • Di Simone Di Giuseppe B; Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, Rome, Italy.
  • Marcellini L; Occupational Health Department, Sant'Andrea University Hospital, Rome, Italy.
  • Anibaldi P; Occupational Health Department, Sant'Andrea University Hospital, Rome, Italy.
  • Marcolongo A; Occupational Health Department, Sant'Andrea University Hospital, Rome, Italy.
  • Simmaco M; Hospital Direction and Clinical Departments, Sant'Andrea University Hospital, Rome, Italy.
  • Borro M; Hospital Direction and Clinical Departments, Sant'Andrea University Hospital, Rome, Italy.
Viral Immunol ; 35(5): 386-389, 2022 06.
Article in English | MEDLINE | ID: covidwho-1931785
ABSTRACT
The kinetics of postvaccination serum anti-Spike IgG concentration were determined in 1,541 health care workers (Sant'Andrea Hospital of Rome, Italy) with no prior infection by SARS-COV-2. Anti-Spike IgG were measured at 3, 12, and 24 weeks after the completion of the primary vaccine cycle (two doses of the BNT162b2 vaccine by Biontech/Pfizer) and 3 weeks apart a third BNT162b2 dose. Stratification of the study population by age (decades from 21-30 to 61-70) highlighted that 24 weeks after cycle completion all age groups had an order of magnitude reduction in serum IgG titers. Considering older adults (age 61-70), they had significantly lower serum IgG titers at each time point compared with younger people, except after the booster dose, which induced similar and elevated IgG titers despite the age.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Aged / Humans / Middle aged Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2022 Document Type: Article Affiliation country: Vim.2022.0026

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Aged / Humans / Middle aged Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2022 Document Type: Article Affiliation country: Vim.2022.0026