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Decay of coronavirus disease 2019 mRNA vaccine-induced immunity in people with HIV.
Woldemeskel, Bezawit A; Karaba, Andrew H; Garliss, Caroline C; Beck, Evan J; Aytenfisu, Tihitina Y; Johnston, Trevor S; Laeyendecker, Oliver; Cox, Andrea L; Blankson, Joel N.
  • Woldemeskel BA; Department of Medicine, Johns Hopkins Medicine.
  • Karaba AH; Department of Medicine, Johns Hopkins Medicine.
  • Garliss CC; Department of Medicine, Johns Hopkins Medicine.
  • Beck EJ; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA.
  • Aytenfisu TY; Department of Medicine, Johns Hopkins Medicine.
  • Johnston TS; Department of Medicine, Johns Hopkins Medicine.
  • Laeyendecker O; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA.
  • Cox AL; Department of Medicine, Johns Hopkins Medicine.
  • Blankson JN; Department of Medicine, Johns Hopkins Medicine.
AIDS ; 36(9): 1315-1317, 2022 07 15.
Article in English | MEDLINE | ID: covidwho-1931985
ABSTRACT
Current coronavirus disease 2019 (COVID-19) mRNA vaccines induce robust SARS-CoV-2-specific humoral and cellular responses in people with HIV (PWH). However, the rate of decay of effector immune responses has not been studied in these individuals. Here, we report a significant waning of antibody responses but persistent T-cell responses 6 months post vaccination in virally suppressed PWH with high CD4+ T-cell counts. These responses are comparable with those seen in healthy donors.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / HIV Infections / COVID-19 Topics: Vaccines Limits: Animals / Humans Language: English Journal: AIDS Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / HIV Infections / COVID-19 Topics: Vaccines Limits: Animals / Humans Language: English Journal: AIDS Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article