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BioHD: An Efficient Genome Sequence Search Platform Using HyperDimensional Memorization
49th IEEE/ACM International Symposium on Computer Architecture, ISCA 2022 ; : 656-669, 2022.
Article in English | Scopus | ID: covidwho-1932798
ABSTRACT
In this paper, we propose BioHD, a novel genomic sequence searching platform based on Hyper-Dimensional Computing (HDC) for hardware-friendly computation. BioHD transforms inherent sequential processes of genome matching to highly-parallelizable computation tasks. We exploit HDC memorization to encode and represent the genome sequences using high-dimensional vectors. Then, it combines the genome sequences to generate an HDC reference library. During the sequence searching, BioHD performs exact or approximate similarity check of an encoded query with the HDC reference library. Our framework simplifes the required sequence matching operations while introducing a statistical model to control the alignment quality. To get actual advantage from BioHD inherent robustness and parallelism, we design a processing in-memory (PIM) architecture with massive parallelism and compatible with the existing crossbar memory. Our PIM architecture supports all essential BioHD operations natively in memory with minimal modifcation on the array. We evaluate BioHD accuracy and efciency on a wide range of genomics data, including COVID-19 databases. Our results indicate that PIM provides 102.8× and 116.1× (9.3× and 13.2×) speedup and energy efciency compared to the state-of-theart pattern matching algorithm running on GeForce RTX 3060 Ti GPU (state-of-the-art PIM accelerator). © 2022 Copyright held by the owner/author(s). Publication rights licensed to ACM.
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Full text: Available Collection: Databases of international organizations Database: Scopus Language: English Journal: ACM International Symposium on Computer Architecture, ISCA 2022 Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Scopus Language: English Journal: ACM International Symposium on Computer Architecture, ISCA 2022 Year: 2022 Document Type: Article