Your browser doesn't support javascript.
The Effect of Vaccination against COVID-19 in Cancer Patients: Final Results of the COICA Trial.
Di Lorenzo, Giuseppe; Ingenito, Concetta; D'Ambrosio, Bruno; Ranieri, Chiara; Iuliucci, Michela Rosaria; Iervolino, Mario; Primiano, Ferdinando; Buonerba, Luciana; Busto, Giuseppina; Ferrara, Claudia; Libroia, Annamaria; Ragone, Gianluca; De Falco, Ferdinando; Costabile, Ferdinando; Fimiani, Pietro; Ugliano, Francesco; Leo, Emilio; Roviello, Giandomenico; Scafuri, Luca; Buonerba, Carlo.
  • Di Lorenzo G; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Ingenito C; Department of Medicine and Health Sciences "Vincenzo Tiberio," University of Molise, Campobasso, Italy.
  • D'Ambrosio B; Associazone O.R.A. - Oncology Research Assistance, Somma Vesuviana, Italy.
  • Ranieri C; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Iuliucci MR; Associazone O.R.A. - Oncology Research Assistance, Somma Vesuviana, Italy.
  • Iervolino M; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Primiano F; Associazone O.R.A. - Oncology Research Assistance, Somma Vesuviana, Italy.
  • Buonerba L; Department of Medicine and Health Sciences "Vincenzo Tiberio," University of Molise, Campobasso, Italy.
  • Busto G; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Ferrara C; Associazone O.R.A. - Oncology Research Assistance, Somma Vesuviana, Italy.
  • Libroia A; General Directorate, ASL Salerno, Salerno, Italy.
  • Ragone G; Medical Directorate, ASL Salerno, Salerno, Italy.
  • De Falco F; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Costabile F; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Fimiani P; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Ugliano F; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Leo E; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Roviello G; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Scafuri L; Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
  • Buonerba C; Associazone O.R.A. - Oncology Research Assistance, Somma Vesuviana, Italy.
Oncology ; 100(9): 512-518, 2022.
Article in English | MEDLINE | ID: covidwho-1932877
ABSTRACT

Background:

The COICA study is an ambispective, observational trial that was conceived to assess the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in cancer patients. A recently published, population-based, case-control study reported a reduced vaccine efficacy at 3-6 months in cancer patients compared to individuals without cancer.

Objectives:

The aim of the study was to describe coronavirus disease 19 (COVID-19) outcomes in cancer patients and analyze differences in SARS-CoV-2 outcomes between vaccinated and unvaccinated patients.

Methods:

Descriptive statistics and frequency counts were used to summarize characteristics of the study population. χ2 test and the log-rank test were used to compare outcomes between vaccinated and unvaccinated patients.

Results:

A total of 141 cancer patients (80 males, 61 females) were recruited at two participating Institutions from March 2020 until April 2022 and observed from the time of positive SARS-CoV-2 test to the time of negativization or death. Approximately 35% of patients had been vaccinated at the time of infection with 2 (16 patients) or 3 (33 patients) vaccine doses. Vaccinated patients consistently and significantly showed improved COVID-19 outcomes compared to unvaccinated patients, with CT-diagnosed pneumonia, hospitalization, O2 therapy, and death reported in 0% versus 48.6%, 2.0% versus 15.2%, 0% versus 14.1%, and 0% versus 7.6%, respectively, of assessable patients (p < 0.05). Vaccinated versus unvaccinated patients showed a significantly shorter time to negativization, with a median (95% confidence interval) time of 12 (10-14) versus 20 (17-23) days, respectively (p < 0.001).

Conclusions:

Vaccination consistently improved all COVID-19 outcomes. No death was recorded among vaccinated patients. Additional research is especially warranted to establish optimal timing and patient selection for administration of the fourth vaccination dose.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 / Neoplasms Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Female / Humans / Male Language: English Journal: Oncology Year: 2022 Document Type: Article Affiliation country: 000525962

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 / Neoplasms Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Female / Humans / Male Language: English Journal: Oncology Year: 2022 Document Type: Article Affiliation country: 000525962