Premenstrual and menstrual changes reported after COVID-19 vaccination: The EVA project.
Womens Health (Lond)
; 18: 17455057221112237, 2022.
Article
in English
| MEDLINE | ID: covidwho-1933041
ABSTRACT
BACKGROUND:
Menstrual disorders were not reported as a possible secondary effect in any of the clinical trials for the SARS-CoV-2 vaccines.AIM:
To describe the prevalence of perceived premenstrual and menstrual changes after COVID-19 vaccine administration.DESIGN:
Cross-sectional study.METHODS:
A total of 14,153 women (mean age 31.5 ± 9.3 years old) who had received the full course of vaccination at least three months earlier were included in this cross-sectional study. Data including the type of vaccine administered, perceived changes in the amount and duration of menstrual bleeding, presence of clots, cycle length, and premenstrual symptoms were collected through a retrospective online survey from June to September 2021.RESULTS:
Of the women who participated in this study, 3136 reported no menstrual changes and 11,017 (78% of the study sample) reported experiencing menstrual cycle changes after vaccination. In summary, women who reported menstrual changes after vaccination were older (overall p < 0.001) and slightly more smokers (p = 0.05) than women who did not report any changes. The most prevalent changes in relation to premenstrual symptoms were increased fatigue (43%), abdominal bloating (37%), irritability (29%), sadness (28%), and headaches (28%). The most predominant menstrual changes were more menstrual bleeding (43%), more menstrual pain (41%), delayed menstruation (38%), fewer days of menstrual bleeding (34.5%), and shorter cycle length (32%).CONCLUSION:
Women vaccinated against COVID-19 usually perceive mild menstrual and premenstrual changes. Future studies are warranted to clarify the physiological mechanisms behind these widely reported changes.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Premenstrual Syndrome
/
COVID-19 Vaccines
/
COVID-19
/
Menstruation Disturbances
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Adult
/
Female
/
Humans
/
Young adult
Language:
English
Journal:
Womens Health (Lond)
Journal subject:
Women's Health
Year:
2022
Document Type:
Article
Affiliation country:
17455057221112237
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